A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407

Crossman, LC, Chaudhuri, RR, Beatson, SA, Wells, TJ, Desvaux, M, Cunningham, AF, Petty, NK, Mahon, V, Brinkley, C, Hobman, JL, Savarino, SJ, Turner, SM, Pallen, MJ, Penn, CW, Parkhill, J, Turner, AK, Johnson, TJ, Thomson, NR, Smith, SGJ and Henderson, IR (2010) A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407. Journal of Bacteriology, 192 21: 5822-5831. doi:10.1128/JB.00710-10


Author Crossman, LC
Chaudhuri, RR
Beatson, SA
Wells, TJ
Desvaux, M
Cunningham, AF
Petty, NK
Mahon, V
Brinkley, C
Hobman, JL
Savarino, SJ
Turner, SM
Pallen, MJ
Penn, CW
Parkhill, J
Turner, AK
Johnson, TJ
Thomson, NR
Smith, SGJ
Henderson, IR
Title A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407
Formatted title A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407
Journal name Journal of Bacteriology   Check publisher's open access policy
ISSN 0021-9193
1067-8832
1098-5530
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1128/JB.00710-10
Volume 192
Issue 21
Start page 5822
End page 5831
Total pages 10
Place of publication Birmingham, AL, United States
Publisher American Society for Microbiology
Collection year 2011
Language eng
Subject 0605 Microbiology
1108 Medical Microbiology
Formatted abstract In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the complete genomic sequence of E. coli H10407, a prototypical strain of enterotoxigenic E. coli, which reproducibly elicits diarrhea in human volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains, revealing that the chromosome is closely related to that of the nonpathogenic commensal strain E. coli HS and to those of the laboratory strains E. coli K-12 and C. Furthermore, these analyses demonstrated that there were no chromosomally encoded factors unique to any sequenced ETEC strains. Comparison of the E. coli H10407 plasmids with those from several ETEC strains revealed that the plasmids had a mosaic structure but that several loci were conserved among ETEC strains. This study provides a genetic context for the vast amount of experimental and epidemiological data that have been published. © 2010, American Society for Microbiology. All Rights Reserved.
Keyword Epithelial-cell Invasion
Heat-labile Enterotoxin
Molecular Characterization
Plasmid Stability
Gene-cluster
Protein
Identification
Secretion
Colonization
Virulence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 31 Oct 2010, 00:08:29 EST