The structure and connectivity of semantic memory in the healthy older adult brain

de Zubicaray, Greig I., Rose, Stephen E. and McMahon, Katie L. (2011) The structure and connectivity of semantic memory in the healthy older adult brain. NeuroImage, 54 2: 1488-1494. doi:10.1016/j.neuroimage.2010.08.058

Author de Zubicaray, Greig I.
Rose, Stephen E.
McMahon, Katie L.
Title The structure and connectivity of semantic memory in the healthy older adult brain
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2011-01-15
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2010.08.058
Volume 54
Issue 2
Start page 1488
End page 1494
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
The anterior temporal lobes (ATLs) have been proposed to serve as a “hub” linking amodal or domain general information about the meaning of words, objects, facts and people distributed throughout the brain in semantic memory. The two primary sources of evidence supporting this proposal, viz. structural imaging studies in semantic dementia (SD) patients and functional imaging investigations, are not without problems. Similarly, knowledge about the anatomo-functional connectivity of semantic memory is limited to a handful of intra-operative electrocortical stimulation (IES) investigations in patients. Here, using principal components analyses (PCA) of a battery of conceptual and non-conceptual tests coupled with voxel based morphometry (VBM) and diffusion tensor imaging (DTI) in a sample of healthy older adults aged 55–85 years, we show that amodal semantic memory relies on a predominantly left lateralised network of grey matter regions involving the ATL, posterior temporal and posterior inferior parietal lobes, with prominent involvement of the left inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus fibre pathways. These results demonstrate relationships between semantic memory, brain structure and connectivity essential for human communication and cognition.
Copyright © 2010 Elsevier Inc. All rights reserved.
Keyword Semantic memory
Anterior temporal lobe
Magnetic resonance imaging
Diffusion tensor imaging
Small world networks
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 31 August 2010.

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Created: Wed, 27 Oct 2010, 16:26:36 EST by Sandrine Ducrot on behalf of School of Psychology