Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy

Pollard, J. D., McCombe, P. A., Baverstock, J., Gatenby, P. A. and McLeod, J. G. (1986) Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy. Journal of Neuroimmunology, 13 2: 123-134. doi:10.1016/0165-5728(86)90059-7


Author Pollard, J. D.
McCombe, P. A.
Baverstock, J.
Gatenby, P. A.
McLeod, J. G.
Title Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
1872-8421
Publication date 1986-12
Sub-type Article (original research)
DOI 10.1016/0165-5728(86)90059-7
Volume 13
Issue 2
Start page 123
End page 134
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The inflammatory infiltrate within human sural nerve, biopsied from six patients with active chronic inflammatory demyelinating neuropathy (CIDP) was studied for T lymphocyte subsets and Class II antigen (Ia)-expressing cells. Immunohistochemical staining with mouse monoclonal antibodies, acid phosphatase staining, and electron microscopy were used to provide an alternative assessment of macrophage and other mononuclear cell numbers. In normal control nerves Class II antigen was present upon endothelial cells, very occasional mononuclear cells and sparsely within the perineurium. In CIDP nerve dense Class II antigen staining was prominent within nerve fascicles, in capillary endothelial cells and within the perineurium. T lymphocytes of suppressor and helper type were present in small numbers only. Moderate numbers of macrophage-monocytes were found in the patients within nerve fascicles but these cells accounted for only part of the dense Ia staining. Since two nerves with hypertrophic changes, Schwann cells forming 'onion bulbs', were clearly Ia positive, the dense and widespread staining in all nerves studied is best explained by Ia antigen expression upon mononuclear and some Schwann cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 102 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 83 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 26 Oct 2010, 11:18:55 EST