Control of DNA repair linked to neuroblastoma differentiation

McCombe, Pam, Lavin, Martin and Kidson, Chev (1976) Control of DNA repair linked to neuroblastoma differentiation. International Journal of Radiation Biology, 29 6: 523-531. doi:10.1080/09553007614550621

Author McCombe, Pam
Lavin, Martin
Kidson, Chev
Title Control of DNA repair linked to neuroblastoma differentiation
Journal name International Journal of Radiation Biology   Check publisher's open access policy
ISSN 0955-3002
Publication date 1976
Sub-type Article (original research)
DOI 10.1080/09553007614550621
Volume 29
Issue 6
Start page 523
End page 531
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract Mouse neuroblastoma cells, which can be induced to undergo reversible differentiation in culture, were used as a model to investigate the effects of ultra violet (U.V.) radiation on terminally differentiated nerve cells. Differentiated neuroblastoma cells were found to be extremely sensitive to U.V. radiation when compared with proliferating cells from the same clone. However, normal resistance was regained if the differentiated cells were allowed to proceed to the next G1 phase of the cell cycle before irradiation. Neuroblastoma cells in the differentiated mode are capable of carrying out some excision repair of DNA damage, but they appear to lack a repair mechanism present in proliferating cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 26 Oct 2010, 11:18:13 EST