Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus: clinical, pathological and immunological features

McCombe, P. A., McLeod, J. G., Pollard, J. D., Guo, Y. P. and Ingall, T. J. (1987) Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus: clinical, pathological and immunological features. Brain, 110 533-549. doi:10.1093/brain/110.2.533


Author McCombe, P. A.
McLeod, J. G.
Pollard, J. D.
Guo, Y. P.
Ingall, T. J.
Title Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus: clinical, pathological and immunological features
Journal name Brain   Check publisher's open access policy
ISSN 0006-8950
1460-2156
Publication date 1987-04
Sub-type Article (original research)
DOI 10.1093/brain/110.2.533
Volume 110
Start page 533
End page 549
Total pages 17
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen within the nerve fascicle, perineurium and within endothelial cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 26 Oct 2010, 11:17:18 EST