Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3

McCombe, P. A., Clark, P., Frith, J. A., Hammond, S. R., Stewart, G. J., Pollard, J. D. and McLeod , J. G. (1985) Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3. Annals of Neurology, 18 4: 514-516. doi:10.1002/ana.410180417


Author McCombe, P. A.
Clark, P.
Frith, J. A.
Hammond, S. R.
Stewart, G. J.
Pollard, J. D.
McLeod , J. G.
Title Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3
Formatted title
α-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3
Journal name Annals of Neurology   Check publisher's open access policy
ISSN 0364-5134
1531-8249
Publication date 1985
Sub-type Other
DOI 10.1002/ana.410180417
Volume 18
Issue 4
Start page 514
End page 516
Total pages 3
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
α-1 Antitrypsin, the major circulating protease inhibitor, has more than thirty alleles that can be identified by electrophoresis. In addition to its role as a protease inhibitor, α-1 antitrypsin may regulate the immune response. As there is evidence that both the inflammatory polyneuropathies and multiple sclerosis have an immune basis, and that genetic factors influence susceptibility, we have determined the α-1 antitrypsin phenotypes (protease inhibitor types) of 63 patients with Guillain-Barre syndrome, 52 patients with chronic inflammatory demyelinating polyneuropathy, and 178 patients with multiple sclerosis. In all 3 groups there was a significant increase in the proportion of patients with the protease inhibitor type M3 allele.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Other
Collection: School of Medicine Publications
 
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Created: Tue, 26 Oct 2010, 11:16:33 EST