Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistan

Hsueah, Po-Ren, Badal, Robert E., Hawser, Stephen P., Hoban, Daryl J., Bouchillon, Samuel K., Ni, Yuxing and Paterson, David L. (2010) Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistance Trends). International Journal of Antimicrobial Agents, 36 5: 408-414. doi:10.1016/j.ijantimicag.2010.07.002


Author Hsueah, Po-Ren
Badal, Robert E.
Hawser, Stephen P.
Hoban, Daryl J.
Bouchillon, Samuel K.
Ni, Yuxing
Paterson, David L.
Title Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)
Journal name International Journal of Antimicrobial Agents   Check publisher's open access policy
ISSN 0924-8579
1872-7913
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1016/j.ijantimicag.2010.07.002
Volume 36
Issue 5
Start page 408
End page 414
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2011
Language eng
Formatted abstract
During 2008, the Study for Monitoring Antimicrobial Resistance Trends (SMART) collected 2370 unique aerobic and facultative Gram-negative bacilli associated with intra-abdominal infections (IAIs) from 32 centres in 11 countries in the Asia-Pacific region and tested their in vitro susceptibility to 12 antimicrobial agents using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. Enterobacteriaceae comprised 88.1% of the isolates, of which Escherichia coli was the most commonly isolated species (47.2%). Very low susceptibility rates to ampicillin/sulbactam were noted, particularly from China (27.4%) and India (28.8%). High rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and Klebsiella pneumoniae were observed in China (59.1% and 34.4%, respectively), India (61.2% and 46.8%, respectively) and Thailand (53.0% and 23.1%, respectively), particularly those causing hospital-associated IAIs. The persistently high rates of E. coli isolates non-susceptible to fluoroquinolones were alarming, especially in Thailand (>50%), China (≥70%) and India (>80%). Twenty percent of ESBL-producing E. coli and 10% of ESBL-producing K. pneumoniae were susceptible to ceftazidime based on the CLSI 2010 guidelines. Carbapenems were the most reliably active in vitro against Enterobacteriaceae. However, isolates of ESBL-producing K. pneumoniae exhibiting non-susceptibility to ertapenem (7.5%) and imipenem (1.9%) emerged, particularly from community-associated IAIs and those isolated from patients in intensive care units. Regular updates of epidemiology and antimicrobial resistance profiles of pathogens associated with IAIs as well as regional treatment guidelines are necessary to ensure optimal antimicrobial therapy.
© 2010 Elsevier B.V. and the International Society of Chemotherapy.
Keyword Intra-abdominal infections
Enterobacteriaceae
Extended-spectrum beta-lactamase (ESBL)
Fluoroquinolones
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 24 Oct 2010, 00:14:07 EST