Prevalence and stability of antibodies to 37 human papillomavirus types: A population-based longitudinal study

Antonsson, Annika, Green, Adele C., Mallitt, Kylie-ann, O'Rourke, Peter K., Pandeya, Nirmala, Pawlita, Michael, Waterboer, Tim and Neale, Rachel E. (2010) Prevalence and stability of antibodies to 37 human papillomavirus types: A population-based longitudinal study. Virology, 407 1: 26-32. doi:10.1016/j.virol.2010.07.046


Author Antonsson, Annika
Green, Adele C.
Mallitt, Kylie-ann
O'Rourke, Peter K.
Pandeya, Nirmala
Pawlita, Michael
Waterboer, Tim
Neale, Rachel E.
Title Prevalence and stability of antibodies to 37 human papillomavirus types: A population-based longitudinal study
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
1096-0341
1089-862X
Publication date 2010-11-10
Sub-type Article (original research)
DOI 10.1016/j.virol.2010.07.046
Volume 407
Issue 1
Start page 26
End page 32
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
Information about serostability of cutaneous HPV types over time is very limited. We investigated seroprevalence and serostability of 37 different HPV types over 4½ years in an Australian population-based study. Sera and data were analyzed for 390 people w ho had never been diagnosed with SCC and had blood collected in 1992, 1993 and 1996.
Eighty-six percent of participants were seropositive to at least one of the 37 HPV types at baseline. HPV-4 was the type with the highest seroprevalence (41%), followed by HPV-38 and HPV-8 (both 33%). Over 90% of people retained their baseline serostatus during the 4½ year follow-up. Highest serostability was observed for HPV-88 (99.7% stayed seropositive or seronegative), while HPV-65 was least stable with 17% altering their serostatus during follow-up.
Seroprevalence to cutaneous HPV types are relatively stable over time, and a single measure can be used as a reasonable marker of long-term antibody status.
© 2010 Published by Elsevier Inc.
Keyword Human papillomavirus
Longitudinal study
Seroprevalence
Antibody stability
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 24 Oct 2010, 00:00:51 EST