FGF9 suppresses meiosis and promotes male germ cell fate in mice

Bowles, Josephine, Feng, Chun-Wei, Spiller, Cassy, Davidson, Tara-Lynne, Jackson, Andrew and Koopman, Peter (2010) FGF9 suppresses meiosis and promotes male germ cell fate in mice. Developmental Cell, 19 3: 440-449. doi:10.1016/j.devcel.2010.08.010

Author Bowles, Josephine
Feng, Chun-Wei
Spiller, Cassy
Davidson, Tara-Lynne
Jackson, Andrew
Koopman, Peter
Title FGF9 suppresses meiosis and promotes male germ cell fate in mice
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
Publication date 2010-09-14
Sub-type Article (original research)
DOI 10.1016/j.devcel.2010.08.010
Volume 19
Issue 3
Start page 440
End page 449
Total pages 10
Editor Deborah Sweet
Emilie Marcus
Place of publication Cambridge, United States
Publisher Cell Press
Collection year 2011
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
Sex determination of mammalian germ cells occurs during fetal development and depends on signals from gonadal somatic cells. Previous studies have established that retinoic acid (RA) triggers ovarian germ cells to enter meiosis and thereby commit to oogenesis, whereas in the developing testis, the enzyme CYP26B1 degrades RA and germ cells are not induced to enter meiosis. Using in vitro and in vivo models, we demonstrate that fibroblast growth factor 9 (FGF9) produced in the fetal testis acts directly on germ cells to inhibit meiosis; in addition, FGF9 maintains expression of pluripotency-related genes and upregulates markers associated with male germ cell fate. We conclude that two independent and mutually antagonistic pathways involving RA and FGF9 act in concert to determine mammalian germ cell sexual fate commitment and support a model in which the mitosis/meiosis switch is robustly controlled by both positive and negative regulatory factors.
© 2010 Elsevier Inc.
Keyword Retinoic acid
Sex determination
Pluripotent cells
Conserved role
Opposing FGF
Mouse gonads
Body axis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 102 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 116 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 17 Oct 2010, 00:14:49 EST