The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways

Gauthier, Marie E. A., Du Pasquier, Louis and Degnan, Bernard M. (2010) The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways. Evolution and Development, 12 5: 519-533. doi:10.1111/j.1525-142X.2010.00436.x

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Author Gauthier, Marie E. A.
Du Pasquier, Louis
Degnan, Bernard M.
Title The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways
Formatted title
The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways
Journal name Evolution and Development   Check publisher's open access policy
ISSN 1520-541X
1525-142X
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1111/j.1525-142X.2010.00436.x
Volume 12
Issue 5
Start page 519
End page 533
Total pages 15
Place of publication Malden, MA
Publisher Blackwell Science
Collection year 2011
Language eng
Subject C1
0603 Evolutionary Biology
0608 Zoology
Abstract P>Members of the Toll-like receptor (TLR) and the interleukin 1 receptor (IL1R) superfamilies activate various signaling cascades that are evolutionarily conserved in eumetazoans. In this study, we have searched the genome and expressed sequence tags of the demosponge Amphimedon queenslandica for molecules involved in TLR and IL1R signaling. Although we did not identify a conventional TLR or ILR, the Amphimedon genome encodes two related receptors, AmqIgTIRs, which are comprised of at least three extracellular IL1R-like immunoglobulins (Ig) and an intracellular TLR-like Toll/interleukin1 receptor/resistance (TIR) domain. The remainder of the TLR/IL1R pathway is mostly conserved in Amphimedon and includes genes known to interact with TLRs and IL1Rs in bilaterians, such as Toll-interacting protein (Tollip) and myeloid differentiation factor 88 (MyD88). By comparing the sponge genome to that of nonmetazoan eukaryotes and other basal animal phyla (i.e., placozoan and cnidarian representatives) we can infer that most components of the signaling cascade, including the receptors, evolved after the divergence of metazoan, and choanoflagellate lineages. In most cases, these proteins are composed of metazoan-specific domains (e.g., Pellino) or architectures (e.g., the association of a death domain with a TIR domain in the MyD88). The dynamic expression of the two AmqIgTIRs, AmqMyD88, AmqTollip, and AmqPellino during Amphimedon embryogenesis and larval development is consistent with the TLR/IL1R pathway having a role in both development and immunity in the last common metazoan ancestor.
Keyword Lipopolysaccharide-binding-protein
Permeabililty-increasing protein
Amino-terminal fragment
NF-KAPPA-B
Immune gne repertoire
LIPID-A binding
Suberites-domuncula
Evolutionary origin
innate immunity
Il-1 Receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 34 times in Scopus Article | Citations
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Created: Sun, 17 Oct 2010, 00:12:42 EST