Decreased semantic competitive inhibition in Parkinson's disease: Evidence from an investigation of word search performance

Arnott, Wendy L., Chenery, Helen J., Angwin, Anthony J., Murdoch, Bruce E., Silburn, Peter A. and Copland, David A. (2010) Decreased semantic competitive inhibition in Parkinson's disease: Evidence from an investigation of word search performance. International Journal of Speech-Language Pathology, 12 5: 437-445. doi:10.3109/17549507.2010.492875


Author Arnott, Wendy L.
Chenery, Helen J.
Angwin, Anthony J.
Murdoch, Bruce E.
Silburn, Peter A.
Copland, David A.
Title Decreased semantic competitive inhibition in Parkinson's disease: Evidence from an investigation of word search performance
Journal name International Journal of Speech-Language Pathology   Check publisher's open access policy
ISSN 1754-9507
1754-9515
Publication date 2010-10
Sub-type Article (original research)
DOI 10.3109/17549507.2010.492875
Volume 12
Issue 5
Start page 437
End page 445
Total pages 9
Place of publication Abingdon, England
Publisher Informa Healthcare
Collection year 2011
Language eng
Abstract Aberrant semantic competitive inhibition has been reported in Parkinson’s disease (PD). Whether PD-related alterations cause an increase or a decrease in lateral inhibition, however, remains unclear. Accordingly, the present study aimed to examine semantic inhibition during lexical-semantic processing in non-demented people with PD. Twenty-two people with PD and 18 matched controls completed a computerized word search task in which both the relationship between the background items and the target (related or unrelated) and the search type (open e.g., any dog or closed e.g., collie) were manipulated. It was hypothesized that decreased semantic inhibition would be evidenced by abnormally short response times for open searches among words related to the target, while increased inhibition would lead to abnormally long response times. Analysis of the results revealed that control participants performed open searches faster for unrelated vs related word lists. In contrast, the PD group recorded similar response times regardless of background items. Hence, the present findings are consistent with the notion of decreased semantic competitive inhibition in PD and suggest that an impaired ability to inhibit unwanted information during lexical retrieval may underlie observed deficits on semantic tasks such as verbal fluency. ©2010 The Speech Pathology Association of Australia Limited.
Keyword Cognitive-linguistic interactions
Expressive Language
Language Processing
Parkinson's disease
Sentence Comprehension
Verbal Fluency
Task
Activation
Retrieval
Deficits
Models
Speed
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Sun, 17 Oct 2010, 00:10:47 EST