Minireview: Nuclear hormone receptor 4A signaling: Implications for metabolic disease

Pearen, Michael A. and Muscat, George E. O. (2010) Minireview: Nuclear hormone receptor 4A signaling: Implications for metabolic disease. Molecular Endocrinology, 24 10: 1891-1903. doi:10.1210/me.2010-0015


Author Pearen, Michael A.
Muscat, George E. O.
Title Minireview: Nuclear hormone receptor 4A signaling: Implications for metabolic disease
Journal name Molecular Endocrinology   Check publisher's open access policy
ISSN 0888-8809
1944-9917
2150-5810
Publication date 2010-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1210/me.2010-0015
Volume 24
Issue 10
Start page 1891
End page 1903
Total pages 13
Editor Donald B. DeFranco
Maggie Haworth
Place of publication Baltimore, MD, U.S.A.
Publisher Endocrine Society
Collection year 2011
Language eng
Formatted abstract
Numerous members of the nuclear hormone receptor (NR) superfamily have been demonstrated to regulate metabolic function in a cell- and tissue-specific manner. This review brings together recent studies that have associated members of the NR superfamily, the orphan NR4A subgroup, with the regulation of metabolic function and disease. The orphan NR4A subgroup includes Nur77 (NR4A1), Nurr1 (NR4A2), and Nor-1 (NR4A3). Expression of these receptors is induced in multiple tissues by a diverse range of stimuli, including stimuli associated with metabolic function, such as: β-adrenoceptor agonists, cold, fatty acids, glucose, insulin, cholesterol, and thiazolidinediones. In vitro and in vivo gain- and loss-of-function studies in major metabolic tissues (including skeletal muscle, adipose, and liver cells and tissues) have associated the NR4A subgroup with specific aspects of lipid, carbohydrate, and energy homeostasis. Most excitingly, although these orphan receptors do not have known endogenous ligands, several small molecule agonists have recently been identified. The preliminary studies reviewed in this manuscript suggest that therapeutic exploitation of the NR4A subgroup may show utility against dyslipidemia, obesity, diabetes, and cardiovascular disease.
Copyright © 2010 by The Endocrine Society.
Keyword Human skeletal muscle
Nur77 Gene expression
Immediate early genes
Antineoplastic agent 6-mercaptopurine
Endothelial-cell growth
Ligand binding domain
Tr3 orphan receptor
NGFI-B
C-FOS
Regulates expression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 17 Oct 2010, 00:05:48 EST