Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia

Bordador, Esmeralda B., Johnson, David W., Henning, Paul, Kennedy, Sean E., McDonald, Stephen P., Burke, John R., McTaggart, Steven J., Australian and New Zealand Dialysis and Transplant Registry (2010) Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia. Pediatric Nephrology, 25 9: 1739-1745. doi:10.1007/s00467-010-1510-5


Author Bordador, Esmeralda B.
Johnson, David W.
Henning, Paul
Kennedy, Sean E.
McDonald, Stephen P.
Burke, John R.
McTaggart, Steven J.
Australian and New Zealand Dialysis
Transplant Registry
Title Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia
Journal name Pediatric Nephrology   Check publisher's open access policy
ISSN 0931-041X
1432-198X
Publication date 2010-09-01
Sub-type Article (original research)
DOI 10.1007/s00467-010-1510-5
Volume 25
Issue 9
Start page 1739
End page 1745
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2011
Language eng
Formatted abstract
Peritonitis is a common complication and major cause of morbidity in children on peritoneal dialysis. In this retrospective longitudinal study, we analysed data retrieved from the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) on 167 patients aged less than 18 years of age who were treated with peritoneal dialysis during the period from October 2003 to December 2007. During this period there were 100 episodes of peritonitis in 57 patients (0.71 episodes/patient-year), with Gram-positive organisms most commonly isolated (44%). Peritonitis occurred frequently in the first 6 months after starting dialysis, with survival analysis showing peritonitis-free survival rates of 72%, 56% and 36% at 6 months, 1 year and 2 years respectively. Age was a weak predictor of peritonitis on univariate analysis, but previous peritonitis was the only significant predictor in a multivariate Cox proportional hazards model (adjusted hazard ratio 2.02; 95% CI: 1.20 to 3.40, p=0.008). Peritonitis episodes infrequently resulted in relapse (5%), recurrence (7%) or the need for either temporary or permanent haemodialysis (5% and 7% respectively) and there were no patient deaths directly attributable to peritonitis. Compared with single organism peritonitis, polymicrobial peritonitis was not associated with any statistically significant differences in outcome. Further prospective studies are required to determine the most appropriate prophylactic measures and antibiotic regimens for use in pediatric patients.
© 2010 IPNA.
Keyword Pediatrics
Peritoneal dialysis
Peritonitis
Guidelines
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 17 Oct 2010, 10:04:12 EST