A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications

Hudson, James E., Frith, Jessica E., Donose, Bogdan C., Rondeau, Elisabeth, Mills, Richard J., Wolvetang, Ernst J., Brooke, Gary P. and Cooper-White, Justin J. (2010) A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications. Biomaterials, 31 31: 7937-7947. doi:10.1016/j.biomaterials.2010.07.007


Author Hudson, James E.
Frith, Jessica E.
Donose, Bogdan C.
Rondeau, Elisabeth
Mills, Richard J.
Wolvetang, Ernst J.
Brooke, Gary P.
Cooper-White, Justin J.
Title A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2010.07.007
Volume 31
Issue 31
Start page 7937
End page 7947
Total pages 11
Place of publication Amsterdam , The Netherlands
Publisher Elsevier
Collection year 2011
Language eng
Subject C1
0904 Chemical Engineering
0903 Biomedical Engineering
Abstract As strategies for manipulating cellular behaviour in vitro and in vivo become more sophisticated, synthetic biomaterial substrates capable of reproducing critical biochemical and biophysical properties (or cues) of tissue micro-environments will be required. Cytoskeletal tension has been shown to be highly deterministic of cell fate decisions, yet few synthetic biomaterials are capable of modulating cytoskeletal tension of adhered cells through variations in stiffness, at least in the ranges applicable to tissue properties (e.g., 1–100 kPa), whilst also possessing other required properties, such as biodegradability, biocompatibility and processability. In this paper we describe a non-cytotoxic polymer system based on acrylated polypropylene glycol triol (aPPGT). This new elastomer system has tunable elastic moduli, is degradable, can be easily surface modified and can be manufactured into porous three dimensional scaffolds or micropatterned substrates. We demonstrate that the PPGT substrates can modulate hMSC morphology, growth, and differentiation, and that they can produce similar outcomes as observed for a non-degradable polyacrylamide substrate, confirming their utility as a degradable elastomer for tissue engineering and other biomedical applications. Crown copyright © 2010 Published by Elsevier Ltd.
Keyword Tissue engineering
Mesenchymal stem cells
Substrate elasticity
Osteogenisis
Adipogeniesis
Mesenchymal Stem Cells
Cross linking
Hydrogels
Growth
Differentiation
Cytoskeleton
Degradation
Fibroblasts
Activation
Scaffolds
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 10 Oct 2010, 00:07:20 EST