A method for achieving super-resolved widefield CARS microscopy

Hajek, KM, Littleton, B, Turk, D, McIntyre, TJ and Rubinsztein-Dunlop, H (2010) A method for achieving super-resolved widefield CARS microscopy. Optics Express, 18 18: 19263-19272. doi:10.1364/OE.18.019263


Author Hajek, KM
Littleton, B
Turk, D
McIntyre, TJ
Rubinsztein-Dunlop, H
Title A method for achieving super-resolved widefield CARS microscopy
Journal name Optics Express   Check publisher's open access policy
ISSN 1094-4087
Publication date 2010-08-30
Sub-type Article (original research)
DOI 10.1364/OE.18.019263
Open Access Status DOI
Volume 18
Issue 18
Start page 19263
End page 19272
Total pages 10
Place of publication Washington, DC, United States
Publisher Optical Society of America
Collection year 2011
Language eng
Abstract We propose a scheme for achieving widefield coherent anti-Stokes Raman scattering (CARS) microscopy images with sub-diffraction-limited resolution. This approach adds structured illumination to the widefield CARS configuration [Applied Physics Letters 84, 816 (2004)]. By capturing a number of images at different phases of the standing wave pattern, an image with up to three times the resolution of the original can be constructed. We develop a theoretical treatment of this system and perform numerical simulations for a typical CARS system, which indicate that resolutions around 120 nm are obtainable with the present scheme. As an imaging system, this method combines the advantages of sub-diffraction-limited resolution, endogenous contrast generation, and a wide field of view. © 2010 OSA
Keyword Stokes raman scattering
Structured illumination microscopy
Fluorescence microscopy
Resolution limit
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2011 Collection
 
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Created: Sun, 10 Oct 2010, 00:01:48 EST