Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications

Hua, Susan and Cabot, Peter J. (2010) Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications. Trends in Pharmacolgical Sciences, 31 9: 427-433. doi:10.1016/j.tips.2010.05.008


Author Hua, Susan
Cabot, Peter J.
Title Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications
Journal name Trends in Pharmacolgical Sciences   Check publisher's open access policy
ISSN 0165-6147
1873-3735
1357-485X
Publication date 2010-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tips.2010.05.008
Volume 31
Issue 9
Start page 427
End page 433
Total pages 7
Editor Lekshmy Balakrishnan
Place of publication London, U.K.
Publisher Elsevier Ltd., Trends Journals
Collection year 2011
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
920116 Skeletal System and Disorders (incl. Arthritis)
Formatted abstract
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an interaction between immune-cell-derived opioids and opioid receptors localized on sensory nerve terminals results in potent, clinically measurable analgesia. Opioid peptides and the mRNA encoding their precursor proteins are present in immune cells. These cells 'home' preferentially to injured tissue, where they secrete opioids to reduce pain. Investigation of the mechanisms underlying the migration of opioid-containing immune cells to inflamed tissue is an active area of research, with recent data demonstrating the importance of cell adhesion molecules in leukocyte adhesion to both the endothelium in vascular transmigration and to neurons within peripheral inflamed tissue. This review summarizes the physiological mechanisms and clinical significance of this unique endogenous peripheral analgesic pathway and discusses therapeutic implications for the development of novel targeted peripheral analgesics.
© 2010 Elsevier Ltd.
Keyword Beta-endorphin
Inflamed tissue
Opioid-peptides
Mast-cells
Intraarticlular morphine
Polymorphonuclear cells
Adhesion-molecule 1
Cholinergic nerves
Pain control
Lymphocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Pharmacy Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 10 Oct 2010, 00:00:19 EST