Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: Associations with indigenous populations and Panton-Valentine leukocidin

Nimmo, G. R., Schooneveldt, J. M., Sutherland, J. L., Power, S., Olesen, D., Selvey, C., Beard, F., Jones, M. and Paterson, D. L. (2010) Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: Associations with indigenous populations and Panton-Valentine leukocidin. European Journal of Clinical Microbiology and Infectious Diseases, 29 10: 1253-1259. doi:10.1007/s10096-010-0994-z


Author Nimmo, G. R.
Schooneveldt, J. M.
Sutherland, J. L.
Power, S.
Olesen, D.
Selvey, C.
Beard, F.
Jones, M.
Paterson, D. L.
Title Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: Associations with indigenous populations and Panton-Valentine leukocidin
Formatted title
Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: Associations with indigenous populations and Panton-Valentine leukocidin
Journal name European Journal of Clinical Microbiology and Infectious Diseases   Check publisher's open access policy
ISSN 0934-9723
1435-4373
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.1007/s10096-010-0994-z
Volume 29
Issue 10
Start page 1253
End page 1259
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2011
Language eng
Formatted abstract
The purpose of this study was to determine the extent of the spread of epidemic clones of non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) and the epidemiology of resultant infections throughout the state of Queensland. We collected a sample of clinical isolates of nmMRSA from laboratories serving public hospitals and clinics throughout the state. Three hundred isolates were typed and tested for the presence of Panton-Valentine leukocidin (PVL) genes and demographic and clinical data were collected from associated cases. Fifteen percent of S. aureus isolates were nmMRSA and 69% of these belonged to PVL-positive clones, predominantly ST93 and CC30. Low numbers of USA300- and USA400-like isolates were also present. Infections due to PVL-positive strains were much less frequently acquired in hospital (3.4%) than those due to PVL-negative nmMRSA (23.7%). Thirty-seven percent of cases were in indigenous people who make up only 3.6% of the general population. The proportion of cases with PVL-positive, but non-negative isolates decreased progressively with age, suggesting that immunity to PVL might be an important determinant of protection. nmMRSA strains are present throughout Queensland and cause infections in both community and healthcare settings.
© 2010 Springer-Verlag.
Keyword Community-associated strains
Changing epidemiology
Necrotizing pneumonia
Controlled study
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 03 Oct 2010, 10:06:24 EST