The molecular regulation of vertebrate limb patterning

Butterfield, Natalie C., McGlinn, Edwina and Wicking, Carol (2010) The molecular regulation of vertebrate limb patterning. Current Topics in Developmental Biology, 90 C: 319-341. doi:10.1016/S0070-2153(10)90009-4

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ217691.pdf HERDC full text - not publicly available application/pdf 5.04MB 1

Author Butterfield, Natalie C.
McGlinn, Edwina
Wicking, Carol
Title The molecular regulation of vertebrate limb patterning
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
ISBN 9780123809124
Publication date 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0070-2153(10)90009-4
Volume 90
Issue C
Start page 319
End page 341
Total pages 23
Editor Peter Koopman
Place of publication San Diego, CA, U.S.A.
Publisher Academic Press
Collection year 2011
Language eng
Subject C1
0601 Biochemistry and Cell Biology
Formatted abstract
The limb has long been considered a paradigm for organogenesis because of its simplicity and ease of manipulation. However, it has become increasingly clear that the processes required to produce a perfectly formed limb involve complex molecular interactions across all three axes of limb development. Old models have evolved with acquisition of molecular knowledge, and in more recent times mathematical modeling approaches have been invoked to explain the precise spatio-temporal regulation of gene networks that coordinate limb patterning and outgrowth. This review focuses on recent advances in our understanding of vertebrate limb development, highlighting the signaling interactions required to lay down the pattern on which the processes of differentiation will act to ultimately produce the final limb.
© 2010 Elsevier Inc.
Keyword Anterior-posterior limb patterning
Proximal-distal limb patterning
Apical ectodermal ridge
Zone of polarizing activity
Intraflagellar transport proteins
Sonic-hedgehog expression
Retinoic acid synthesis
Pectoral fin bud
Feedback loop
Hox genes
Positional information
Repressor functions
Developing embryo
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Volume title: Organogenesis in Development

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 03 Oct 2010, 00:02:24 EST