The game plan: Cellular and molecular mechanisms of mammalian testis development

Wainwright, EN and Wilhelm, D (2010) The game plan: Cellular and molecular mechanisms of mammalian testis development. Current Topics in Developmental Biology, 90 C: 231-262. doi:10.1016/S0070-2153(10)90006-9

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Author Wainwright, EN
Wilhelm, D
Title The game plan: Cellular and molecular mechanisms of mammalian testis development
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
1557-8933
ISBN 9780123809124
0123809126
Publication date 2010-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0070-2153(10)90006-9
Volume 90
Issue C
Start page 231
End page 262
Total pages 32
Place of publication San Diego, CA, U.S.A.
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
In mammals, biological differences between males and females, which influence many aspects of their physical, social, and psychological environments, are solely determined genetically. In the presence of a Y chromosome, the gonadal primordium will differentiate into a testis, whereas in the absence of the Y chromosome an ovary will develop. Testis and ovary subsequently direct the differentiation of all secondary sex characteristics down the male and female pathway, respectively. The male-determining factor on the Y chromosome, SRY, was identified some 20 years ago. Since then, significant progress has been made toward understanding the molecular and cellular pathways that result in the formation of a testis. Here, we review what is known about testis differentiation in mice and humans, with reference to other species where appropriate.
© 2010 Elsevier Inc.
Keyword Gonad development
Sertoli cells
Sex determination
Sox9
Sry
Testis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 03 Oct 2010, 10:02:16 EST