TP53 codon 72 polymorphism is associated with age at onset of glioblastoma

El Hallani, S., Ducray, F., Idbaih, A., Marie, Y., Boisselier, B., Colin, C., Laigle-Donadey, F., Rodéro, M., Chinot, O., Thillet, J., Hoang-Xuan, K., Delattre, J-Y. and Sanson, M. (2009) TP53 codon 72 polymorphism is associated with age at onset of glioblastoma. Neurology, 72 4: 332-336. doi:10.1212/01.wnl.0000341277.74885.ec


Author El Hallani, S.
Ducray, F.
Idbaih, A.
Marie, Y.
Boisselier, B.
Colin, C.
Laigle-Donadey, F.
Rodéro, M.
Chinot, O.
Thillet, J.
Hoang-Xuan, K.
Delattre, J-Y.
Sanson, M.
Title TP53 codon 72 polymorphism is associated with age at onset of glioblastoma
Journal name Neurology   Check publisher's open access policy
ISSN 0028-3878
Publication date 2009-01-27
Sub-type Article (original research)
DOI 10.1212/01.wnl.0000341277.74885.ec
Volume 72
Issue 4
Start page 332
End page 336
Total pages 5
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 1109 Neurosciences
Formatted abstract
Background: Functional single nucleotide polymorphisms (SNP) in codon 72 of TP53 have been shown to be a risk factor, a prognostic marker, and related factor to age at onset in various cancers.

Methods:
We investigated blood samples from 254 patients with glioblastoma and 238 healthy controls.

Results:
TP53 codon 72 status was not correlated with prognosis and did not differ between glioblastoma and control populations. However, the Pro/Pro genotype was overrepresented in patients <45 years (20.6% vs 6.4% in patients with glioblastoma >45 years, p = 0.002, vs 5.9% in control group, p = 0.001). We then confirmed this result on an independent series of young patients with glioblastoma. Finally, the analysis of tumor DNA found the Pro allele associated with occurrence of TP53 somatic mutation.

Conclusion: Our data suggest that TP53 functional variation is particularly critical for oncogenesis of glioblastoma in young patients.
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Wed, 29 Sep 2010, 10:22:33 EST by Laura McTaggart on behalf of UQ Centre for Clinical Research