Plasmodium falciparum: New molecular targets with potential for antimalarial drug development

Gardiner, Donald L., Skinner-Adams, Tina S., Brown, Christopher L., Andrews, Katherine T., Stack, Colin M., McCarthy, James S., Dalton, John P. and Trenholme, Katharine R. (2009) Plasmodium falciparum: New molecular targets with potential for antimalarial drug development. Expert Review of Anti-Infective Therapy, 7 9: 1087-1098. doi:10.1586/ERI.09.93


Author Gardiner, Donald L.
Skinner-Adams, Tina S.
Brown, Christopher L.
Andrews, Katherine T.
Stack, Colin M.
McCarthy, James S.
Dalton, John P.
Trenholme, Katharine R.
Title Plasmodium falciparum: New molecular targets with potential for antimalarial drug development
Formatted title
Plasmodium falciparum: New molecular targets with potential for antimalarial drug development
Journal name Expert Review of Anti-Infective Therapy   Check publisher's open access policy
ISSN 1478-7210
1744-8336
Publication date 2009-11
Sub-type Article (original research)
DOI 10.1586/ERI.09.93
Volume 7
Issue 9
Start page 1087
End page 1098
Total pages 12
Place of publication London, U.K.
Publisher Expert Reviews
Language eng
Subject 11 Medical and Health Sciences
Formatted abstract
Malaria remains one of the world’s most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine–xanthine–guanine phosphoribosyltransferase.
Keyword Aminopeptidase
Aspartic protease
Histone deacetylase
Hypoxanthine-xanthine- guanine phosphoribosyltransferase
Malaria
Molecular target
Plasmepsin
Plasmodium falciparum
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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Created: Wed, 29 Sep 2010, 09:36:42 EST by Laura McTaggart on behalf of Faculty Of Health Sciences