The leukemic stem cell niche: Current concepts and therapeutic opportunities

Lane, Steven W., Scadden, David T. and Gilliland, D. Gary (2009) The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood, 114 6: 1150-1157. doi:10.1182/blood-2009-01-202606


Author Lane, Steven W.
Scadden, David T.
Gilliland, D. Gary
Title The leukemic stem cell niche: Current concepts and therapeutic opportunities
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
Publication date 2009-08-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1182/blood-2009-01-202606
Volume 114
Issue 6
Start page 1150
End page 1157
Total pages 7
Place of publication United States
Publisher American Society of Hematology
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
Formatted abstract
The genetic events that contribute to the pathogenesis of acute myeloid leukemia are among the best characterized of all human malignancies. However, with notable exceptions such as acute promyelocytic leukemia, significant improvements in outcome based on these insights have not been forthcoming. Acute myeloid leukemia is a paradigm of cancer stem (or leukemia initiating) cells with hierarchy analogous to that seen in hematopoiesis. Normal hematopoiesis requires complex bidirectional interactions between the bone marrow microenvironment (or niche) and hematopoietic stem cells (HSCs). These interactions are critical for the maintenance of normal HSC quiescence and perturbations can influence HSC self-renewal. Leukemia stem cells (LSCs), which also possess limitless self-renewal, may hijack these homeostatic mechanisms, take refuge within the sanctuary of the niche during chemotherapy, and consequently contribute to eventual disease relapse. We will discuss the emerging evidence supporting the importance of the bone marrow microenvironment in LSC survival and consider the physiologic interactions of HSCs and the niche that inform our understanding of microenvironment support of LSCs. Finally, we will discuss approaches for the rational development of therapies that target the microenvironment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 222 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 245 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 29 Sep 2010, 19:11:30 EST by Laura McTaggart on behalf of Faculty Of Health Sciences