The global burden of iron overload

Wood, Marnie J., Skoien, Richard and Powell, Lawrie W. (2009) The global burden of iron overload. Hepatology International, 3 3: 434-444. doi:10.1007/s12072-009-9144-z


Author Wood, Marnie J.
Skoien, Richard
Powell, Lawrie W.
Title The global burden of iron overload
Journal name Hepatology International   Check publisher's open access policy
ISSN 1936-0533
Publication date 2009
Sub-type Article (original research)
DOI 10.1007/s12072-009-9144-z
Volume 3
Issue 3
Start page 434
End page 444
Total pages 11
Place of publication United States
Publisher Springer New York LLC
Language eng
Subject 11 Medical and Health Sciences
Formatted abstract
There have been major developments in the field of iron metabolism in the past decade following the identification of the HFE gene and the mutation responsible for the C282Y substitution in the HFE protein. While HFE-associated hemochromatosis occurs predominantly in people of northern European extraction, other less-common mutations can lead to the same clinical syndrome and these may occur in other populations in the Asian-Pacific region. The most common of these is the mutation that leads to changes in the ferroportin molecule, the protein responsible for the transport of iron across the basolateral membrane of the enterocyte and from macrophages. Recent research has unraveled the molecular processes of iron transport and regulation of how these are disturbed in hemochromatosis and other iron-loading disorders. At the same time, at least one new oral iron chelating agent has been developed that shows promise in the therapy of hemochromatosis as well as thalassemia and other secondary causes of iron overload. It is pertinent therefore to examine the developments in the global field of iron overload that have provided insights into the pathogenesis, disease penetrance, comorbid factors, and management.
Keyword Haemochromatosis
Iron metabolism
HFE haemochromatosis
Secondary iron overload
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 28 Sep 2010, 13:20:48 EST by Laura McTaggart on behalf of Faculty Of Health Sciences