Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction

Manske, S. L., Liu-Ambrose, T., Cooper, D. M. L., Kontulainen, S., Guy, P., Forster, B. B. and McKay, H. A. (2009) Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction. Osteoporosis International, 20 3: 445-453. doi:10.1007/s00198-008-0675-2


Author Manske, S. L.
Liu-Ambrose, T.
Cooper, D. M. L.
Kontulainen, S.
Guy, P.
Forster, B. B.
McKay, H. A.
Title Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction
Journal name Osteoporosis International   Check publisher's open access policy
ISSN 0937-941X
1433-2965
Publication date 2009-03
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00198-008-0675-2
Volume 20
Issue 3
Start page 445
End page 453
Total pages 9
Place of publication London, U.K.
Publisher Springer International
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Summary: We examined the contributions of femoral neck cortical and trabecular bone to proximal femur failure load. We found that trabecular bone mineral density explained a significant proportion of variance in failure load after accounting for total bone size and cortical bone mineral content or cortical area.

Introduction: The relative contribution of femoral neck trabecular and cortical bone to proximal femur failure load is unclear.

Objectives: Our primary objective was to determine whether trabecular bone mineral density (TbBMD) contributes to proximal femur failure load after accounting for total bone size and cortical bone content. Our secondary objective was to describe regional differences in the relationship among cortical bone, trabecular bone, and failure load within a cross-section of the femoral neck.

Materials and methods: We imaged 36 human cadaveric proximal femora using quantitative computed tomography (QCT). We report total bone area (ToA), cortical area (CoA), cortical bone mineral content (CoBMC), and TbBMD measured in the femoral neck cross-section and eight 45° regions. The femora were loaded to failure.

Results and observations: Trabecular bone mineral density explained a significant proportion of variance in failure load after accounting for ToA and then either CoBMC or CoA respectively. CoBMC contributed significantly to failure load in all regions of the femoral neck except the posterior region. TbBMD contributed significantly to failure load in all regions of the femoral neck except the inferoanterior, superoposterior, and the posterior regions.

Conclusion: Both cortical and trabecular bone make significant contributions to failure load in ex vivo measures of bone strength.
© 2008 International Osteoporosis Foundation and National Osteoporosis Foundation.
Keyword Bone strength
Cortical bone
Femoral neck
Proximal femur
QCT
Trabecular bone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online: 26 July 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Mon, 27 Sep 2010, 14:00:48 EST by Jon Swabey on behalf of Faculty Of Health Sciences