RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology

Liu, Jingquan, Tao, Lei, Xu, Jiangtao, Jia, Zhongfan, Boyer, Cyrille and Davis, Thomas P. (2009) RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology. Polymer, 50 19: 4455-4463. doi:10.1016/j.polymer.2009.07.018


Author Liu, Jingquan
Tao, Lei
Xu, Jiangtao
Jia, Zhongfan
Boyer, Cyrille
Davis, Thomas P.
Title RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a 'core-first' methodology
Formatted title
RAFT controlled synthesis of six-armed biodegradable star polymeric architectures via a ‘core-first’ methodology
Journal name Polymer   Check publisher's open access policy
ISSN 0032-3861
1873-2291
Publication date 2009-09-10
Sub-type Article (original research)
DOI 10.1016/j.polymer.2009.07.018
Volume 50
Issue 19
Start page 4455
End page 4463
Total pages 9
Place of publication London, U.K.
Publisher Elsevier
Language eng
Subject 03 Chemical Sciences
09 Engineering
Formatted abstract
Six-armed biodegradable star polymers made from polystyrene (polySt), poly(polyethylene glycol) acrylate (polyPEG-A) and the block copolymer, polySt-b-polyPEG-A were synthesized using a ‘core-first’ methodology via RAFT polymerization. Disulfide linkages between the core and the arms conferred biodegradability on the stars. The star architectures were found to degrade rapidly on treatment with DL-dithiothreitol (DTT) and degrade more slowly in the presence of glutathione (GSH), the most abundant intracellular thiol tethered peptide. These star polymers were well characterized using gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), electrospray ionization mass spectroscopy (ESI-MS) and dynamic light scattering (DLS).
© 2009 Elsevier Ltd. All rights reserved.
Keyword Biodegradable polymer
RAFT
Star polymer
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Mon, 27 Sep 2010, 09:20:34 EST by Jon Swabey on behalf of Aust Institute for Bioengineering & Nanotechnology