The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes

Phillips, L. K., Peake, J. M., Zhang, X., Hickman, I. J., Kolade, O., Sacre, J. W., Huang, B. E., Simpson, P., Li, S. H., Whitehead, J. P., Sharman, J. E., Martin, J. H. and Prins, J. B. (2010) The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 95 9: 4455-4459. doi:10.1210/jc.2010-0413

Author Phillips, L. K.
Peake, J. M.
Zhang, X.
Hickman, I. J.
Kolade, O.
Sacre, J. W.
Huang, B. E.
Simpson, P.
Li, S. H.
Whitehead, J. P.
Sharman, J. E.
Martin, J. H.
Prins, J. B.
Title The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1210/jc.2010-0413
Volume 95
Issue 9
Start page 4455
End page 4459
Total pages 5
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Collection year 2011
Language eng
Formatted abstract
Context: Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) is a measure of systemic arterial stiffness and independently predicts cardiovascular outcome.

Objective: The objective of this study was to assess the effect of a standardized high-fat meal on metabolic parameters and AIx in 1) lean, 2) obese nondiabetic, and 3) subjects with type 2 diabetes mellitus (T2DM).

Design and Setting:
Male subjects (lean, n = 8; obese, n = 10; and T2DM, n = 10) were studied for 6 h after a high-fat meal and water control. Glucose, insulin, triglycerides, and AIx (radial applanation tonometry) were measured serially to determine the incremental area under the curve (iAUC).

AIx decreased in all three groups after a high-fat meal. A greater overall postprandial reduction in AIx was seen in lean and T2DM compared with obese subjects (iAUC, 2251 ± 1204, 2764 ± 1102, and 1187 ± 429% · min, respectively; P < 0.05). The time to return to baseline AIx was significantly delayed in subjects with T2DM (297 ± 68 min) compared with lean subjects (161 ± 88 min; P < 0.05). There was a significant correlation between iAUC AIx and iAUC triglycerides (r = 0.50; P < 0.05).

Obesity is associated with an attenuated overall postprandial decrease in AIx. Subjects with T2DM have a preserved, but significantly prolonged, reduction in AIx after a high-fat meal. The correlation between AIx and triglycerides suggests that postprandial dysmetabolism may impact on vascular dynamics. The markedly different response observed in the obese subjects compared with those with T2DM was unexpected and warrants additional evaluation. Copyright © 2010 by The Endocrine Society.
Keyword Insulin-induced decreases
Wave reflection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 26 Sep 2010, 00:04:01 EST