Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects

Banovic, Tatjana, MacDonald , Kelli P. A., Markey, Kate A., Morris, Edward S., Kuns, Rachel D., Varelias, Antiopi and Hill, Geofffrey R. (2009) Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects. Biology of Blood and Marrow Transplantation, 15 1: 126-130. doi:10.1016/j.bbmt.2008.11.019

Author Banovic, Tatjana
MacDonald , Kelli P. A.
Markey, Kate A.
Morris, Edward S.
Kuns, Rachel D.
Varelias, Antiopi
Hill, Geofffrey R.
Title Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects
Journal name Biology of Blood and Marrow Transplantation   Check publisher's open access policy
ISSN 1083-8791
Publication date 2009-01
Sub-type Article (original research)
DOI 10.1016/j.bbmt.2008.11.019
Volume 15
Issue 1
Start page 126
End page 130
Total pages 5
Place of publication United States of America
Publisher Elseiver
Language eng
Subject 1103 Clinical Sciences
Abstract Donor treatment with granulocyle-colony stimulating factor (G-CSF) is known to modulate immune function, characterized by the generation of regulatory myelogenous and T cell populations and Th2 differentiation. Recently, these effects have been shown to be enhanced by pegylation of the G-CSF molecule, which also improves graft-versus-leukemia (GVL) via activation of invariant natural killer (iNK) T cells. We have compared G-CSF bound to a single PEG molecule (monopeg-G-CSF) as used clinically to a G-CSF molecule bound to multiple PEG molecules (multipeg-G-CSF) in major histocompatibility complex (MHC) disparate and matched models of graft-versus-host disease (GVHD) and GVL. We demonstrate that multipeg-G-CSF induces greater levels of progenitor cell, myelogenous, and iNKT cell expansion than monopeg-G-CSF, while inducing similar protection from GVHD. Despite this, multipeg-G-CSF enhanced CTL function in vivo and improved iNKT cell-dependent leukemia clearance. Thus, GVL and GVHD can be further separated after allogeneic stem cell transplantation by mobilization with a multiple-pegylated G-CSF molecule. © 2009 American Society for Blood and Marrow Transplantation.
Keyword Graft-versus-host disease
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 23 Sep 2010, 14:24:31 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences