Animal performance and stress: responses and tolerance limits at different levels of biological organisation

Kassahn, Karin S., Crozier, Ross H., Pörtner, Hans O. and Caley, M. Julian (2009) Animal performance and stress: responses and tolerance limits at different levels of biological organisation. Biological Reviews, 84 2: 277-292. doi:10.1111/j.1469-185X.2008.00073.x

Author Kassahn, Karin S.
Crozier, Ross H.
Pörtner, Hans O.
Caley, M. Julian
Title Animal performance and stress: responses and tolerance limits at different levels of biological organisation
Journal name Biological Reviews   Check publisher's open access policy
ISSN 1464-7931
Publication date 2009-05
Sub-type Article (original research)
DOI 10.1111/j.1469-185X.2008.00073.x
Volume 84
Issue 2
Start page 277
End page 292
Total pages 16
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 06 Biological Sciences
Formatted abstract
Recent advances in molecular biology and the use of DNA microarrays for gene expression profiling are providing new insights into the animal stress response, particularly the effects of stress on gene regulation. However, interpretation of the complex transcriptional changes that occur during stress still poses many challenges because the relationship between changes at the transcriptional level and other levels of biological organisation is not well understood. To confront these challenges, a conceptual model linking physiological and transcriptional responses to stress would be helpful. Here, we provide the basis for one such model by synthesising data from organismal, endocrine, cellular, molecular, and genomic studies. We show using available examples from ectothermic vertebrates that reduced oxygen levels and oxidative stress are common to many stress conditions and that the responses to different types of stress, such as environmental, handling and confinement stress, often converge at the challenge of dealing with oxygen imbalance and oxidative stress. As a result, a common set of stress responses exists that is largely independent of the type of stressor applied. These common responses include the repair of DNA and protein damage, cell cycle arrest or apoptosis, changes in cellular metabolism that reflect the transition from a state of cellular growth to one of cellular repair, the release of stress hormones, changes in mitochondrial densities and properties, changes in oxygen transport capacities and changes in cardio-respiratory function. Changes at the transcriptional level recapitulate these common responses, with many stress-responsive genes functioning in cell cycle control, regulation of transcription, protein turnover, metabolism, and cellular repair. These common transcriptional responses to stress appear coordinated by only a limited number of stress-inducible and redox-sensitive transcription factors and signal transduction pathways, such as the immediate early genes c-fos and c-jun, the transcription factors NFκB and HIF-1α, and the JNK and p38 kinase signalling pathways. As an example of environmental stress responses, we present temperature response curves at organismal, cellular and molecular levels. Acclimation and physiological adjustments that can shift the threshold temperatures for the onset of these responses are discussed and include, for example, adjustments of the oxygen delivery system, the heat shock response, cellular repair system, and transcriptome. Ultimately, however, an organism’s ability to cope with environmental change is largely determined by its ability to maintain aerobic scope and to prevent loss in performance. These systemic constraints can determine an organism’s long-term survival well before cellular and molecular functions are disturbed. The conceptual model we propose here discusses some of the crosslinks between responses at different levels of biological organisation and the central role of oxygen balance and oxidative stress in eliciting these responses with the aim to help the interpretation of environmental genomic data in the context of organismal function and performance.
Keyword environmental stress
transcriptional stress responses
environmental genomics
oxidative stress
organismal response curves
aerobic scope
environmental tolerance
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 85 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 90 times in Scopus Article | Citations
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Created: Thu, 23 Sep 2010, 13:08:40 EST by Laura McTaggart on behalf of Institute for Molecular Bioscience