Analysis of recurrent events: A systematic review of randomised controlled trials of interventions to prevent falls

Donaldson, Meghan G., Sobolev, Boris, Cook, Wendy L., Janssen, Patti A. and Khan, Karim M. (2009) Analysis of recurrent events: A systematic review of randomised controlled trials of interventions to prevent falls. Age and Ageing, 38 2: 151-155. doi:10.1093/ageing/afn279


Author Donaldson, Meghan G.
Sobolev, Boris
Cook, Wendy L.
Janssen, Patti A.
Khan, Karim M.
Title Analysis of recurrent events: A systematic review of randomised controlled trials of interventions to prevent falls
Journal name Age and Ageing   Check publisher's open access policy
ISSN 0002-0729
1468-2834
Publication date 2009-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/ageing/afn279
Volume 38
Issue 2
Start page 151
End page 155
Total pages 5
Place of publication Oxford, U.K.
Publisher Oxford University Press
Language eng
Subject 1103 Clinical Sciences
1701 Psychology
Formatted abstract
Rationale: there are several well-developed statistical methods for analysing recurrent events. Although there are guidelines for reporting the design and methodology of randomised controlled trials (RCTs), analysis guidelines do not exist to guide the analysis for RCTs with recurrent events. Application of statistical methods that do not account for recurrent events may provide erroneous results when used to test the efficacy of an intervention. It is unknown what proportion of RCTs of falls prevention studies have utilised statistical methods that incorporate recurrent events.

Methods: we conducted a systematic review of RCTs of interventions to prevent falls in community-dwelling older persons. We searched Medline from 1994 to November 2006. We determined the proportion of studies that reported using three statistical methods appropriate for the analysis of recurrent events (negative binomial regression, Andersen–Gill extension of the Cox model and the WLW marginal model).

Results: fewer than one-third of 83 papers that reported falls as an outcome utilised any appropriate statistical method (negative binomial regression, Andersen–Gill extension of the Cox model and Cox marginal model) to analyse recurrent events and fewer than 15% utilised graphical methods to represent falls data.

Conclusion: RCTs that have a recurrent event end-point should include an analysis appropriate for recurrent event data such as negative binomial regression, Andersen–Gill extension of the Cox model and/or the WLW marginal model. We recommend that researchers and clinicians seek consultation with a statistician with expertise in recurrent event methodology.
© The Author 2008. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
Keyword Recurrent events
Falls
Elderly
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published under "Systematic Review".

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Thu, 23 Sep 2010, 11:37:24 EST by Jon Swabey on behalf of Faculty Of Health Sciences