Alloimmune neonatal neutropenia linked to anti-HNA-4a

Fung, Y. L., Pitcher, L. A., Willett, J. E., Reed, C., Mison, L., Bux, J., Eiber, G. and Minchinton, R. M. (2003) Alloimmune neonatal neutropenia linked to anti-HNA-4a. Transfusion Medicine, 13 1: 49-52. doi:10.1046/j.1365-3148.2003.00413.x


Author Fung, Y. L.
Pitcher, L. A.
Willett, J. E.
Reed, C.
Mison, L.
Bux, J.
Eiber, G.
Minchinton, R. M.
Title Alloimmune neonatal neutropenia linked to anti-HNA-4a
Journal name Transfusion Medicine   Check publisher's open access policy
ISSN 0958-7578
1365-3148
Publication date 2003-01
Sub-type Article (original research)
DOI 10.1046/j.1365-3148.2003.00413.x
Volume 13
Issue 1
Start page 49
End page 52
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract This is a novel case report of alloimmune neonatal neutropenia (ANN) linked to the neutrophil antibody anti-HNA-4a (MART). Since its discovery, the HNA-4a antigen has never been associated with any clinical neutropenia. A first-born neonate with respiratory distress was found to be severely neutropenic, because of ANN. The broad reactivity of the antibody together with its capture by CD11b and CD18 in monoclonal antibody immobilization of granulocyte antigen test suggested HNA-4a specificity. DNA sequencing confirmed that the father is HNA-4a-positive and that the mother is HNA-4a-negative, supporting the diagnosis of ANN linked to MART.
Keyword Alloimmune neonatal neutropenia
DNA sequencing
HNA-4a
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 22 Sep 2010, 09:46:14 EST