Managing passively acquired autoimmune neonatal neutropenia: A case study

Fung, Y. L., Pitcher, L. A., Taylor, K. and Minchinton, R. M. (2005) Managing passively acquired autoimmune neonatal neutropenia: A case study. Transfusion Medicine, 15 2: 151-155. doi:10.1111/j.0958-7578.2005.00565.x

Author Fung, Y. L.
Pitcher, L. A.
Taylor, K.
Minchinton, R. M.
Title Managing passively acquired autoimmune neonatal neutropenia: A case study
Journal name Transfusion Medicine   Check publisher's open access policy
ISSN 0958-7578
Publication date 2005-04
Sub-type Article (original research)
DOI 10.1111/j.0958-7578.2005.00565.x
Volume 15
Issue 2
Start page 151
End page 155
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Pregnant women with autoimmune neutropenia (AIN) and circulating neutrophil-specific autoantibodies can deliver neutropenic neonates at risk of sepsis. We report the case of a woman who had two such pregnancies. The woman had been on prophylactic granulocyte colony-stimulating factor (G-CSF) treatment, but this was ceased prior to conception in both pregnancies. In the first pregnancy, there was no monitoring or interventions, and the neonate was neutropenic and required intensive care treatment. In the second pregnancy, the maternal neutrophil autoantibody level was monitored, and G-CSF treatment was introduced in the third trimester. The second infant had no neutropenia at delivery and an excellent Apgar score. We discuss the management strategy in the second pregnancy that included monitoring of serial titres of the maternal autoantibody and the introduction of G-CSF in the third trimester, which may have contributed to a more favourable clinical outcome. This may assist other clinicians faced with similar dilemmas in the future.
Keyword Autoimmune neutropenia
Neonatal neutropenia
Passively acquired
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 22 Sep 2010, 09:46:10 EST