Exploring retinal and functional markers of diabetic neuropathy

Shahidi, Ayda M., Sampson, Geoff P., Pritchard, Nicola, Edwards, Katie, Russell, Anthony, Malik, Rayaz A. and Efron, Nathan (2010) Exploring retinal and functional markers of diabetic neuropathy. Clinical and Experimental Optometry, 93 5: 309-323. doi:10.1111/j.1444-0938.2010.00491.x

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Author Shahidi, Ayda M.
Sampson, Geoff P.
Pritchard, Nicola
Edwards, Katie
Russell, Anthony
Malik, Rayaz A.
Efron, Nathan
Title Exploring retinal and functional markers of diabetic neuropathy
Journal name Clinical and Experimental Optometry   Check publisher's open access policy
ISSN 0816-4622
Publication date 2010-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1444-0938.2010.00491.x
Volume 93
Issue 5
Start page 309
End page 323
Total pages 15
Editor H. Barry Collin
Place of publication Carlton, VIC, Australia
Publisher Australian Optometrical Association
Collection year 2011
Language eng
Formatted abstract
Diabetic peripheral neuropathy (DPN) is one of the most debilitating complications of diabetes. DPN is a major cause of foot ulceration and lower limb amputation. Early diagnosis and management are key factors in reducing morbidity and mortality. Current techniques for clinical assessment of DPN are relatively insensitive for detecting early disease or involve invasive procedures such as skin biopsies. There is a need for less painful, non-invasive, safe evaluation methods. Eye-care professionals already play an important role in the management of diabetic retinopathy but recent studies have indicated that the eye may also be an important site for the diagnosis and monitoring of neuropathy. Corneal nerve morphology is a promising marker of diabetic neuropathy occurring elsewhere in the body. Emerging evidence tentatively suggests that retinal anatomical markers and a range of functional visual indicators could similarly provide useful information regarding neural damage in diabetes, although this line of research is less well established. This review outlines the growing body of evidence supporting a potential diagnostic role for retinal structure and visual functional markers in the diagnosis and monitoring of peripheral neuropathy in diabetes.
© 2010 The Authors.
Clinical and Experimental Optometry © 2010 Optometrists Association Australia.
Keyword Diabetes mellitus
Optical coherence tomography
Peripheral neuropathy
Visual fields
Visual function
Nerve-fiber layer
Scanning laser polarimetry
Corneal confocal microscopy
Ganglion-cell death
Contrast sensitivity
Multifocal electroretinogram
Oscillatory potentials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
UQ Diamantina Institute Publications
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Created: Sun, 19 Sep 2010, 00:07:22 EST