Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women

Levinger, Itamar, Howlett, Kirsten F., Peake, Jonathan, Garnham, Andrew, Hare, David L., Jerums, George, Selig, Steve and Goodman, Craig (2010) Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women. Exercise Immunology Review, 16 98-104.

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Name Description MIMEType Size Downloads
Author Levinger, Itamar
Howlett, Kirsten F.
Peake, Jonathan
Garnham, Andrew
Hare, David L.
Jerums, George
Selig, Steve
Goodman, Craig
Title Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women
Journal name Exercise Immunology Review   Check publisher's open access policy
ISSN 1077-5552
Publication date 2010
Sub-type Critical review of research, literature review, critical commentary
Volume 16
Start page 98
End page 104
Total pages 7
Editor Hinnak Northoff
Derek Zieker
Place of publication Greven, Germany
Publisher WWF Verlag
Collection year 2011
Language eng
Formatted abstract
Aims: This study investigated the association between the basal (rest) insulin-signaling proteins, Akt, and the Akt substrate AS160, metabolic risk factors, inflammatory markers and aerobic fitness, in middle-aged women with varying numbers of metabolic risk factors for type 2 diabetes.

Methods: Sixteen women (n=16) aged 51.3±5.1 (mean ±SD) years provided muscle biopsies and blood samples at rest. In addition, anthropometric characteristics and aerobic power were assessed and the number of metabolic risk factors for each participant was determined (IDF criteria).

Results: The mean number of metabolic risk factors was 1.6±1.2. Total Akt was negatively correlated with IL-1β (r = −0.45, p = 0.046), IL-6 (r = −0.44, p = 0.052) and TNF-α (r = −0.51, p = 0.025). Phosphorylated AS160 was positively correlated with HDL (r = 0.58, p= 0.024) and aerobic fitness (r = 0.51, p=0.047). Furthermore, a multiple regression analysis revealed that both HDL (t=2.5, p=0.032) and VO2peak (t=2.4, p=0.037) were better predictors for phosphorylated AS160 than TNF-α or IL-6 (p>0.05).

Conclusions: Elevated inflammatory markers and increased metabolic risk factors may inhibit insulin-signaling protein phosphorylation in middle-aged women, thereby increasing insulin resistance under basal conditions. Furthermore, higher HDL and fitness levels are associated with an increased AS160 phosphorylation, which may in turn reduce insulin resistance.
Keyword Insulin signaling
Inflammation
Cytokines
Aerobic fitness
Insulin-receptor substrate-1
Skeletal-muscle
Glucose-transport
Kinase-activity
Resistance
Phosphorylation
Inflammation
Alpha
Individuals
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Sun, 19 Sep 2010, 00:06:45 EST