Increasing incidence of candidaemia: long-term epidemiological trends, Queensland, Australia, 1999-2008

Playford, E. G., Nimmo, G. R., Tilse, M. and Sorrell, T. C. (2010) Increasing incidence of candidaemia: long-term epidemiological trends, Queensland, Australia, 1999-2008. Journal of Hospital Infection, 76 1: 46-51. doi:10.1016/j.jhin.2010.01.022

Author Playford, E. G.
Nimmo, G. R.
Tilse, M.
Sorrell, T. C.
Title Increasing incidence of candidaemia: long-term epidemiological trends, Queensland, Australia, 1999-2008
Journal name Journal of Hospital Infection   Check publisher's open access policy
ISSN 0195-6701
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1016/j.jhin.2010.01.022
Volume 76
Issue 1
Start page 46
End page 51
Total pages 6
Place of publication London
Publisher W B Saunders
Collection year 2011
Language eng
Formatted abstract
Given variability in the epidemiology of candidaemia and a relative paucity of contemporary longitudinal data, a passive laboratory-based surveillance study was performed to assess the epidemiology of candidaemia in all public healthcare facilities in Queensland, Australia over the period 1999-2008. Demographic and microbiological data on all candidaemia episodes, together with appropriate denominators (admissions and patient-days), were collected from laboratory and administrative information systems. From 1999 to 2008, 1137 episodes occurred (overall incidence-density: 0.45 per 10 000 patient-days) with a 3.5-fold increase in density (P<0.0001 for trend). Candidaemia episodes originating in traditional high-risk areas either decreased (haemato-oncology and paediatric wards) or remained stable (intensive care units). Episodes on adult medical/surgical wards increased significantly over time, accounting for 60% of the total by 2008. The relative proportion caused by Candida albicans decreased and Candida parapsilosis increased (both P<0.01). The proportion of fluconazole-resistant isolates did not change. The increasing occurrence of candidaemia outside traditional high-risk areas and the emergence of C. parapsilosis present new challenges for preventive and early intervention strategies. © 2010 The Hospital Infection Society.
Keyword Candidaemia
Blood-stream Infections
In-vitro Susceptibilities
Secular Trends
United States
Active Surveillance
Species Infections
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 26 June 2009 Accepted 15 January 2010 Available online 10 April 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 19 Sep 2010, 00:04:36 EST