Synthesis and evaluation of partly fluorinated polyelectrolytes as components in F-19 MRI-detectable nanoparticles

Nurmi, Leena, Peng, Hui, Seppälä, Jukka, Haddleton, David M., Blakey, Idriss and Whittaker, Andrew K. (2010) Synthesis and evaluation of partly fluorinated polyelectrolytes as components in F-19 MRI-detectable nanoparticles. Polymer Chemistry, 1 7: 1039-1047. doi:10.1039/c0py00035c

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Author Nurmi, Leena
Peng, Hui
Seppälä, Jukka
Haddleton, David M.
Blakey, Idriss
Whittaker, Andrew K.
Title Synthesis and evaluation of partly fluorinated polyelectrolytes as components in F-19 MRI-detectable nanoparticles
Formatted title
Synthesis and evaluation of partly fluorinated polyelectrolytes as components in 19F MRI-detectable nanoparticles
Journal name Polymer Chemistry   Check publisher's open access policy
ISSN 1759-9954
1759-9962
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1039/c0py00035c
Open Access Status Not Open Access
Volume 1
Issue 7
Start page 1039
End page 1047
Total pages 9
Editor David Haddleton
Place of publication Cambridge, U.K.
Publisher Royal Society of Chemistry
Collection year 2011
Language eng
Subject C1
0303 Macromolecular and Materials Chemistry
0912 Materials Engineering
Formatted abstract
A series of partly fluorinated polyelectrolytes were synthesized by transition metal mediated living radical polymerization and evaluated for their applicability as corona-forming components in 19F MRI-detectable nanoparticles in aqueous solutions. The polymers were statistical and block copolymers of trifluoroethyl methacrylate (TFEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). The polymers were either directly dissolved in water (statistical copolymers), or assembled into aqueous nanoparticles with PTFEMA cores and P(TFEMA-co-DMAEMA) coronas (block copolymers). The polymer composition, polymer charge density, solution ionic strength and solution pH were varied. The 19F spin–lattice (T1) and spin–spin (T2) relaxation times and 19F image intensities of solutions of the polymers were measured and related to polymer structure and aqueous conformation. The 19F NMR T2 relaxation times were found to be highly indicative of the 19F imaging performance. Maintaining sufficient mobility of the 19F nuclei was important for obtaining images of high intensity. 19F mobility could be increased by preventing their aggregation in water by exploiting electrostatic repulsion between monomer units.
© The Royal Society of Chemistry 2010
Keyword Radical polymerization
Poly (N, N-dimethylaminoethyl methacrylate)
Magnetic-resonance
NMR relaxation
Copolymers
Globule
Transition
Adsorption
Molecules
Dynamics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 19 Sep 2010, 00:02:43 EST