Validation of a parent-proxy quality of life questionnaire for paediatric chronic cough (PC-QOL)

Newcombe, Peter A., Sheffield, Jeanie K., Juniper, Elizabeth F., Petsky, Helen L., Willis, Carol and Chang, Anne B. (2010) Validation of a parent-proxy quality of life questionnaire for paediatric chronic cough (PC-QOL). Thorax, 65 9: 819-823. doi:10.1136/thx.2009.133868


Author Newcombe, Peter A.
Sheffield, Jeanie K.
Juniper, Elizabeth F.
Petsky, Helen L.
Willis, Carol
Chang, Anne B.
Title Validation of a parent-proxy quality of life questionnaire for paediatric chronic cough (PC-QOL)
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
Publication date 2010-09-01
Sub-type Article (original research)
DOI 10.1136/thx.2009.133868
Volume 65
Issue 9
Start page 819
End page 823
Total pages 5
Place of publication London
Publisher BMJ Publishing
Collection year 2011
Language eng
Formatted abstract
Background: Quality of life (QOL) measures are an important patient-relevant outcome measure for clinical studies. Currently there is no fully validated cough-specific QOL measure for paediatrics. The objective of this study was to validate a cough-specific QOL questionnaire for paediatric use. Method: 43 children (28 males, 15 females; median age 29 months, IQR 20-41 months) newly referred for chronic cough participated. One parent of each child completed the 27-item Parent Cough-Specific QOL questionnaire (PC-QOL), and the generic child (Pediatric QOL Inventory 4.0 (PedsQL)) and parent QOL questionnaires (SF-12) and two cough-related measures (visual analogue score and verbal category descriptive score) on two occasions separated by 2-3 weeks. Cough counts were also objectively measured on both occasions. Results: Internal consistency for both the domains and total PC-QOL at both test times was excellent (Cronbach alpha range 0.70-0.97). Evidence for repeatability and criterion validity was established, with significant correlations over time and significant relationships with the cough measures. The PC-QOL was sensitive to change across the test times and these changes were significantly related to changes in cough measures (PC-QOL with: verbal category descriptive score, rs=-0.37, p=0.016; visual analogue score, rs=-0.47, p=0.003). Significant correlations of the difference scores for the social domain of the PC-QOL and the domain and total scores of the PedsQL were also noted (rs=0.46, p=0.034). Conclusion: The PC-QOL is a reliable and valid outcome measure that assesses QOL related to childhood cough at a given time point and measures changes in cough-specific QOL over time.
Keyword Health-status
Children
Reliability
Validity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 20 December 2009; Accepted 26 May 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Nursing, Midwifery and Social Work Publications
School of Psychology Publications
 
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Created: Sun, 19 Sep 2010, 10:01:35 EST