Alleviation of lead poisoning in the brain with aqueous leaf extract of the Thunbergia laurifolia (Linn.)

Tangpong, Jitbanjong and Satarug, Soisungwan (2010). Alleviation of lead poisoning in the brain with aqueous leaf extract of the Thunbergia laurifolia (Linn.). In: , Toxicology Letters: Proceedings of an International Conference on Cadmium in Food and Human Health. International Conference on Cadmium in Food and Human Health, Phitsanulok, Thailand, (83-88). 15-17 January, 2010.

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Author Tangpong, Jitbanjong
Satarug, Soisungwan
Title of paper Alleviation of lead poisoning in the brain with aqueous leaf extract of the Thunbergia laurifolia (Linn.)
Conference name International Conference on Cadmium in Food and Human Health
Conference location Phitsanulok, Thailand
Conference dates 15-17 January, 2010
Proceedings title Toxicology Letters: Proceedings of an International Conference on Cadmium in Food and Human Health   Check publisher's open access policy
Journal name Toxicology Letters   Check publisher's open access policy
Place of Publication Amstedam, The Netherlands
Publisher Elsevier/North-Holland
Publication Year 2010
Sub-type Fully published paper
DOI 10.1016/j.toxlet.2010.04.031
ISSN 0378-4274
Volume 198
Issue 1
Start page 83
End page 88
Total pages 5
Collection year 2011
Language eng
Abstract/Summary We used seven groups of 8-week-old male ICR mice, with 6 mice in each group, to test if aqueous leaf extract of the Thai medicinal plant Thunbergia laurifolia Linn. (TL) protects against lead poisoning. We found that co-treatment with aqueous TL leaf extract did not affect levels of lead in blood and brain of mice given lead in drinking water at 1 g/L for 8 weeks. However, co-treatment with aqueous TL leaf extract at 100 mg/kg or 200 mg/kg body weight was found to alleviate adverse effects of lead on learning deficit and memory loss, evaluated with water maze swimming test. Further, increased activity of the cell-death marker enzyme caspase-3 was observed in the brain of mice treated with lead, thereby suggesting that the memory loss could be caused by lead-induced loss of neurons in the brain. Co-treatment with aqueous TL leaf extract at 100 mg/kg or 200 mg/kg body weight was found to restore the levels of caspase-3 activity and maintain total anti-oxidant capacity and anti-oxidant enzymes in the brain. TL leaf extract thus reduced neuronal cell death and memory loss caused by lead uptake in mice, and the anti-oxidant activities of the TL leaf extract might account for these effects.
Subjects E1
1103 Clinical Sciences
Keyword Lead
Thunbergia launfolia Linn. (TL)
Memory loss
Neurotoxicity
Oxidative stress
Water maze
Renal-function Biomarkers
Glutathione-peroxidase
Oxidative Stress
In-vitro
Lipid-peroxidation
Hepatic Cyp2a6
Rat-brain
Red Wine
Antioxidant
Exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 19 Sep 2010, 00:01:22 EST