Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand

Honda, Ryumon, Swaddiwudhipong, Witaya, Nishijo, Muneko, Mahasakpan, Pranee, Teeyakasem, Wimonrat, Ruangyuttikarn, Werawan, Satarug, Soisungwan, Padungtod, Chantana and Nakagawa, Hideaki (2010). Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand. In: Toxicology Letters: Proceedings of an International Conference on Cadmium in Food and Human Health. International Conference on Cadmium in Food and Human Health, Phitsanulok, Thailand, (26-32). 15-17 January, 2010. doi:10.1016/j.toxlet.2010.04.023

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Author Honda, Ryumon
Swaddiwudhipong, Witaya
Nishijo, Muneko
Mahasakpan, Pranee
Teeyakasem, Wimonrat
Ruangyuttikarn, Werawan
Satarug, Soisungwan
Padungtod, Chantana
Nakagawa, Hideaki
Title of paper Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
Conference name International Conference on Cadmium in Food and Human Health
Conference location Phitsanulok, Thailand
Conference dates 15-17 January, 2010
Proceedings title Toxicology Letters: Proceedings of an International Conference on Cadmium in Food and Human Health   Check publisher's open access policy
Journal name Toxicology Letters   Check publisher's open access policy
Place of Publication Amstedam, The Netherlands
Publisher Elsevier/North-Holland
Publication Year 2010
Sub-type Fully published paper
DOI 10.1016/j.toxlet.2010.04.023
ISSN 0378-4274
Volume 198
Issue 1
Start page 26
End page 32
Total pages 6
Collection year 2011
Language eng
Formatted Abstract/Summary
High levels of cadmium (Cd) in paddy soil and rice, and a concurrent increase in urinary Cd of inhabitants in the Mae Sot District, Tak Province, Thailand first emerged in 2003. Risk factors such as occupation, sources of staple food and drinking water as well as biomarkers of adverse renal effects of the increased body burden of Cd were investigated in 795 residents, 30 years or older, whose urinary Cd levels were between 0.02 and 106 μg/g creatinine. Farmers who consumed their own rice and residents who sourced drinking water from wells and/or the river demonstrated increased urinary Cd. Age-adjusted mean urinary cadmium for male and female subjects who consumed well water was 5.7 μg/g vs. 6.1 μg/g creatinine while the corresponding value for male and female subjects who did not consume well water was 3.7 μg/g vs. 4.8 μg/g creatinine, respectively. Increased urinary levels of β2-microglobulin and N-acetyl-β-d-glucosaminidase were observed with the increase in urinary Cd, indicating tubular dysfunction and renal damage associated with increase in Cd body burden. Consumption of well water and rice grown in the contaminated area increase the body burden of Cd. Cessation of exposure is essential to prevent and possibly recover from Cd toxicity, especially among the residents whose kidney damage and malfunction may be reversible.
Subjects C1
1103 Clinical Sciences
Keyword Urinary cadmium
Renal tubular dysfunction
Risk factor
Farmer
Beta(2)-microglobulin (beta 2-MG)
N-acetyl-beta-D-glucosaminidase (NAG)
Jinzu River-basin
Dose-response Relationship
Logistic-regression Analysis
Mae Sot District
Environmental Cadmium
Toyama-prefecture
Polluted Area
Exposed Population
Tubular Dysfunction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 19 Sep 2010, 00:00:52 EST