The amygdala and anxiety after epilepsy surgery

Halley, SA, Wrench, JM, Reutens, DC and Wilson, SJ (2010) The amygdala and anxiety after epilepsy surgery. Epilepsy and Behavior, 18 4: 431-436. doi:10.1016/j.yebeh.2010.05.003


Author Halley, SA
Wrench, JM
Reutens, DC
Wilson, SJ
Title The amygdala and anxiety after epilepsy surgery
Journal name Epilepsy and Behavior   Check publisher's open access policy
ISSN 1525-5050
1525-5069
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1016/j.yebeh.2010.05.003
Volume 18
Issue 4
Start page 431
End page 436
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
The relationship between amygdalar volume and anxiety after epilepsy surgery was explored. Participants comprised patients who underwent mesial temporal (n= 26) or non-mesial temporal resections (n= 16) and 41 neurologically normal controls. Anxiety was prospectively measured preoperatively and for the first 12 months postoperatively using criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Amygdalar volumetry was performed on preoperative and control T1-weighted MRI scans. Resection of an ipsilateral amygdala of normal volume, relative to controls, was associated with postoperative anxiety in patients with mesial temporal resections, regardless of seizure outcome [F(1, 22). = 5.17, P< 0.05]. There was no relationship between amygdalar volume and anxiety in patients with non-mesial temporal resections, or between contralateral amygdalar volume and anxiety in patients with mesial temporal resections (P> 0.05 for all comparisons). In conclusion, resection or deafferentation of an amygdala with a volume within the normal range was associated with increased postoperative anxiety. © 2010 Elsevier Inc.
Keyword Epilepsy
Surgical outcome
Prospective
Psychopathology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Centre for Advanced Imaging Publications
 
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Created: Sun, 12 Sep 2010, 00:04:58 EST