Use of physiologic measurements of left ventricular function to guide clinical practice.

James Hare (2010). Use of physiologic measurements of left ventricular function to guide clinical practice. PhD Thesis, School of Medicine, The University of Queensland.

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s41081534_phd_abstract.pdf Final Thesis Lodgement application/pdf 29.08KB 3
s41081534_phd_totalthesis.pdf s41081534_phd_totalthesis.pdf application/pdf 24.04MB 16
Author James Hare
Thesis Title Use of physiologic measurements of left ventricular function to guide clinical practice.
School, Centre or Institute School of Medicine
Institution The University of Queensland
Publication date 2010-04
Thesis type PhD Thesis
Supervisor Professor Thomas Marwick
Total pages 246
Total colour pages 18
Total black and white pages 228
Subjects 11 Medical and Health Sciences
Abstract/Summary Assessment of left ventricular (LV) function is one of the most common requests made to cardiac imaging services. This demand stems from a large body of evidence that shows abnormal LV systolic and, more recently, diastolic function has important prognostic and treatment related implications for patients with a wide range of cardiovascular diseases. The vast majority of information supporting the use of conventional measures of LV function, such as ejection fraction, originates from population studies and large clinical trials. However, the application of these measurements to individual patients is far less defined, especially when used for serial evaluation. Central to these concerns is the relative paucity of data surrounding the test-retest reliability of conventional measures in clinical settings. Newer measures of LV function have been developed over recent years, with several techniques becoming widely used in clinical practice (i.e. tissue Doppler imaging) and others remaining largely research tools (i.e. 3D echocardiography, tissue strain/strain rate). Possible benefits of new technologies include improved identification and early detection of myocardial disease, improved reliability for monitoring progression of disease, and the development of novel methods to assess response to therapy. Despite this potential, the application and clinical utility of these techniques above and beyond more conventional measures remains in many cases to be adequately characterized. This thesis addresses several of these issues: from variability of novel and conventional measures of LV function in clinical practice, to new applications of novel functional measures in clinical settings.
Keyword left ventricle
Clinical practice
myocardial function
ejection fraction
Additional Notes Colour Pages: 26, 39, 44, 46, 50-52, 58, 59, 61, 62, 77, 79, 106, 115-117, 171 Landscape Pages: 35, 36, 81-84, 87-90, 93-96, 98, 101

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Created: Sat, 11 Sep 2010, 16:01:04 EST by Dr James Hare on behalf of Library - Information Access Service