Interactions between H-2 and O-18 natural abundance variations and DLW measurements of energy expenditure

Ritz, P., Cole, T.J., Davies, P.S.W., Goldberg, G.R. and Coward, W.A. (1996) Interactions between H-2 and O-18 natural abundance variations and DLW measurements of energy expenditure. American Journal of Physiology-Endocrinology and Metabolism, 271 2: E302-E308.


Author Ritz, P.
Cole, T.J.
Davies, P.S.W.
Goldberg, G.R.
Coward, W.A.
Title Interactions between H-2 and O-18 natural abundance variations and DLW measurements of energy expenditure
Formatted title
Interactions between H-2 and O-18 natural abundance variations and DLW measurements of energy expenditure
Journal name American Journal of Physiology-Endocrinology and Metabolism   Check publisher's open access policy
ISSN 1522-1555
Publication date 1996-08
Sub-type Article (original research)
Volume 271
Issue 2
Start page E302
End page E308
Total pages 6
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Language eng
Subject 1111 Nutrition and Dietetics
Formatted abstract
Appropriate corrections for 2H and 18O natural abundance are necessary in energy expenditure measurements with the doubly labeled water (DLW) method. The contribution of natural abundance variations to errors in the method is generally ignored if an appropriate dose level is given. Calculation of the appropriate dose level assumes that 2H and 18O natural abundance values are covariant and have a fixed slope. This study has investigated the between- and within-subject natural abundance variations, the latter over periods of time similar to those used in DLW experiment. Although 2H and 18O natural abundance values are covariant between subjects, the slope of their relationship is different from that of the Meteoric Water Line. Within subjects there is no such demonstrable covariance. It is concluded that: 1) the determinants of 2H and 18O natural abundance are different within and between subjects; 2) the concept of an optimal ratio of doses is not valid, and a safer strategy is probably to use a ratio > 10; 3) natural abundance variations may contribute significantly to the magnitude of error in the DLW measurements of energy expenditure.
Keyword Doubly-labeled-water
Exercise
(H2O)-H-2-O-18
Validation
Soldiers
Humans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 08 Sep 2010, 09:36:36 EST