Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release

Blacklay, A., Grossman, A., Ross, R.J.M., Savage, M.O., Davies, P.S.W., Plowman, P.N., Coy, D.H. and Besser, G.M. (1986) Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release. Journal of Endocrinology, 108 1: 25-29. doi:10.1677/joe.0.1080025


Author Blacklay, A.
Grossman, A.
Ross, R.J.M.
Savage, M.O.
Davies, P.S.W.
Plowman, P.N.
Coy, D.H.
Besser, G.M.
Title Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 1479-6805
0022-0795
Publication date 1986-01
Sub-type Article (original research)
DOI 10.1677/joe.0.1080025
Volume 108
Issue 1
Start page 25
End page 29
Total pages 5
Place of publication Bristol, England
Publisher Portland Press for the Society for Endocrinology
Language eng
Subject 1112 Oncology and Carcinogenesis
1114 Paediatrics and Reproductive Medicine
Formatted abstract
A synthetic 29-amino acid analogue of human pancreatic GH-releasing hormone (GHRH(1-29)NH2) has recently been shown to stimulate the release of GH in normal subjects. We have studied the GH response to GHRH(1-29)NH2 in nine children irradiated for brain and nasopharyngeal tumours, who were not growing and were deficient in GH as assessed by insulin-induced hypoglycaemia. Serum GH rose in response to GHRH(1-29)NH2 in all the children, and in five the peak serum GH response was >20 mu./1. The data suggest that when hypothalamo-pituitary irradiation results in GH deficiency, this is due to a failure of the synthesis or delivery of endogenous GHRH from the hypothalamus to the pituitary cells. It also suggests that it may be possible to treat such children using synthetic GHRH in place of exogenous GH.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 08 Sep 2010, 09:31:01 EST