Mechanisms of resistance of bacteria causing ventilator-associated pneumonia

Szabo, Dora, Silveira, Fernanda, Fujitani, Shigeki and Paterson, David L. (2005) Mechanisms of resistance of bacteria causing ventilator-associated pneumonia. Clinics in Chest Medicine, 26 1: 75-79. doi:10.1016/j.ccm.2004.10.004

Author Szabo, Dora
Silveira, Fernanda
Fujitani, Shigeki
Paterson, David L.
Title Mechanisms of resistance of bacteria causing ventilator-associated pneumonia
Journal name Clinics in Chest Medicine   Check publisher's open access policy
ISSN 0272-5231
Publication date 2005-03
Sub-type Article (original research)
DOI 10.1016/j.ccm.2004.10.004
Volume 26
Issue 1
Start page 75
End page 79
Total pages 5
Place of publication Philadelphia ; London
Publisher Saunders
Language eng
Subject 1103 Clinical Sciences
1117 Public Health and Health Services
Abstract The common causes of ventilator-associated pneumonia (Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter spp) are frequently resistant to multiple antibiotic classes. S aureus develops resistance to all beta-lactam antibiotics by producing a modified penicillin-binding protein. Linezolid resistance arises by way of mutations in the 23S ribosomal subunit. Antibiotic resistance in gram-negative bacilli usually arises by way of beta-lactamase production, upregulation of efflux pumps, or loss of outer membrane proteins. The ability of bacteria to develop and disseminate new mechanisms of antibiotic resistance may outstrip the availability of new antibiotic classes.
Keyword Staphylococcus-aureus
Linezolid Resistance
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 07 Sep 2010, 17:12:49 EST