Aspergillus infections in transplant recipients

Singh, Nina and Paterson, David L. (2005) Aspergillus infections in transplant recipients. Clinical Microbiology Reviews, 18 1: 44-69. doi:10.1128/CMR.18.1.44-69.2005

Author Singh, Nina
Paterson, David L.
Title Aspergillus infections in transplant recipients
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
Publication date 2005-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/CMR.18.1.44-69.2005
Volume 18
Issue 1
Start page 44
End page 69
Total pages 26
Place of publication Washington, D.C. U.S.A.
Publisher American Society for Microbiology
Language eng
Subject 1103 Clinical Sciences
1117 Public Health and Health Services
Abstract Aspergillus infections are occurring with an increasing frequency in transplant recipients. Notable changes in the epidemiologic characteristics of this infection have occurred; these include a change in risk factors and later onset of infection. Management of invasive aspergillosis continues to be challenging, and the mortality rate, despite the use of newer antifungal agents, remains unacceptably high. Performing molecular studies to discern new targets for antifungal activity, identifying signaling pathways that may be amenable to immunologic interventions, assessing combination regimens of antifungal agents or combining antifungal agents with modulation of the host defense mechanisms, and devising diagnostic assays that can rapidly and reliably diagnose infections represent areas for future investigations that may lead to further improvement in outcomes.
Keyword Invasive Fungal-infections
Stem-cell Transplantation
Liposomal Amphotericin-B
Chronic Granulomatous-disease
Allergic Bronchopulmonary Aspergillosis
Colony-stimulating Factor
Real-time PCR
Orthotopic Liver-transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
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Created: Tue, 07 Sep 2010, 17:12:13 EST