Pulmonary fungal infections

Silveira, F. and Paterson, D.L. (2005) Pulmonary fungal infections. Current Opinion in Pulmonary Medicine, 11 3: 242-246. doi:10.1097/01.mcp.0000159832.20648.70

Author Silveira, F.
Paterson, D.L.
Title Pulmonary fungal infections
Journal name Current Opinion in Pulmonary Medicine   Check publisher's open access policy
ISSN 1070-5287
Publication date 2005-05
Sub-type Article (original research)
DOI 10.1097/01.mcp.0000159832.20648.70
Volume 11
Issue 3
Start page 242
End page 246
Total pages 5
Place of publication Philadelphia, PA, U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject 1103 Clinical Sciences
1117 Public Health and Health Services
Formatted abstract
Purpose of review:
Invasive fungal infections of the lung have historically been associated with an extremely high mortality. This review aims to disseminate the most recent advances in the diagnosis and management of fungal infections of the lung.

Recent findings:
The number and diversity of immunosuppressed populations are growing rapidly. Transplant immunosuppression is becoming more aggressive early in the posttransplant period, potentially increasing the risk of invasive fungal infections. The galactomannan antigen test and the β-D-glucan test have emerged as methods of serially monitoring at-risk patients for invasive aspergillosis. Their utility has been established in some neutropenic populations but not in solid organ transplant recipients. In-vitro studies, animal studies, and retrospective human studies support the use of combination antifungal therapy for invasive aspergillosis. Unfortunately no randomized clinical trials exist.


Invasive pulmonary aspergillosis will continue to be a major problem in immunocompromised patients in the future. Immense advances in the last 2-3 years are sure to improve outcome. Well-designed multicenter evaluations are still necessary, however, to optimize management as management options widen. © 2005 Lippincott Williams & Wilkins.
Keyword Aspergillosis
Liver-transplant Recipients
Stem-cell Transplantation
Aspergillus-galactomannan Antigen
Receiving Piperacillin-tazobactam
Invasive Aspergillosis
Circulating Galactomannan
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Tue, 07 Sep 2010, 17:11:55 EST