Antibiotic-resistant infections in the critically ill adult

Silveira, Fernanda, Fujitani, Shigeki and Paterson, David L. (2004) Antibiotic-resistant infections in the critically ill adult. Clinics in Laboratory Medicine, 24 2: 329-341. doi:10.1016/j.cll.2004.03.002

Author Silveira, Fernanda
Fujitani, Shigeki
Paterson, David L.
Title Antibiotic-resistant infections in the critically ill adult
Journal name Clinics in Laboratory Medicine   Check publisher's open access policy
ISSN 0272-2712
Publication date 2004-06
Sub-type Article (original research)
DOI 10.1016/j.cll.2004.03.002
Volume 24
Issue 2
Start page 329
End page 341
Total pages 13
Place of publication Philadelphia ; London ; Sydney
Publisher Saunders
Language eng
Subject 1103 Clinical Sciences
1117 Public Health and Health Services
Abstract Intensive care units (ICUs) frequently are the epicenter of nosocomial infections with antibiotic-resistant bacteria. Optimization of antibiotic therapy for seriously ill patients with bacterial infections appears to have a strong influence on outcome. Laboratories can aid in provision of appropriate antibiotic therapy by providing clinicians with "antibiograms" to aid empiric antibiotic choice and by providing minimal inhibitory concentrations of key antibiotics so that antibiotic dosing is optimized to key pharmacodynamic targets. Laboratories also play a crucial role in the prevention of antibiotic resistance in the ICU. Molecular epidemiologic evidence of an oligoclonal outbreak of infections orients prevention measures toward investigation of common environmental sources of infection and prevention of patient-to-patient transmission. In contrast, evidence of polyclonality shifts prevention of antibiotic resistance to antibiotic management strategies.
Keyword Spectrum-beta-lactamase
Ventilator-associated Pneumonia
Inadequate Antimicrobial Treatment
Gram-negative Bacilli
Enterococcal Infections
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 07 Sep 2010, 17:11:51 EST