In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)

Rossi, Flávia, Baquero, Fernando, Hsueh, Po-Ren, Paterson, David L., Bochicchio, Grant V., Snyder, Theresa A., Satishchandran, Vilas, McCarroll, Kathleen, DiNubile, Mark J. and Chow, Joseph W. (2006) In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends). Journal of Antimicrobial Chemotherapy, 58 1: 205-210. doi:10.1093/jac/dkl199


Author Rossi, Flávia
Baquero, Fernando
Hsueh, Po-Ren
Paterson, David L.
Bochicchio, Grant V.
Snyder, Theresa A.
Satishchandran, Vilas
McCarroll, Kathleen
DiNubile, Mark J.
Chow, Joseph W.
Title In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
1460-2091
Publication date 2006-07
Sub-type Article (original research)
DOI 10.1093/jac/dkl199
Volume 58
Issue 1
Start page 205
End page 210
Total pages 6
Place of publication London, England
Publisher Oxford University Press
Language eng
Subject 1103 Clinical Sciences
1117 Public Health and Health Services
Formatted abstract
Objectives:
SMART (Study for Monitoring Antimicrobial Resistance Trends) is an ongoing study to monitor worldwide antimicrobial resistance trends among aerobic and facultatively anaerobic Gram-negative bacilli (GNB) isolated from intra-abdominal infections. This 2004 report summarizes the most recently completed annual data from SMART.

Methods:
During 2004, 81 medical centres from 28 countries in five global regions collected intra-abdominal GNB for antimicrobial susceptibility testing using broth microdilution according to the Clinical and Laboratory Standards Institute guidelines.

Results:
A total of 6156 unique aerobic and facultatively anaerobic GNB were isolated from intra-abdominal infections. Enterobacteriaceae composed 86% of the total isolates. Among the 12 antimicrobial agents tested, the carbapenems and amikacin were the most consistently active against the Enterobacteriaceae. Escherichia coli was the most commonly isolated species (48%), and the susceptibility rate to the quinolones was lowest in Asia/Pacific and Latin America. Extended-spectrum β-lactamases (ESBLs) were detected phenotypically in 10% of E. coli, 17% of Klebsiella spp. and 22% of Enterobacter spp. worldwide, representing a slight increase over the two previous years. ESBL producers typically had a more antibiotic-resistant profile than non-ESBL producers but were usually susceptible to the carbapenems.

Conclusions:
Antimicrobial resistance among GNB isolated from intra-abdominal infections continued to be a problem worldwide in 2004, with the highest rates of resistance overall in the Asia/Pacific region. The carbapenems and amikacin were the most consistently active agents in vitro against Enterobacteriaceae isolated from intra-abdominal infections worldwide. © 2006 Oxford University Press.
Keyword Enterobacteriaceae
In vitro susceptibility
Antimicrobial Susceptibility
Extended-spectrum beta-lactamases
ES13Ls
Spectrum Beta-lactamases
Fluoroquinolone Resistance
Therapy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Tue, 07 Sep 2010, 17:11:21 EST