Failure to detect Chlamydia pneumoniae in atherosclerotic plaques of Australian patients

Paterson, David L., Hall, Jennifer, Rasmussen, Stephanie J. and Timms, Peter (1998) Failure to detect Chlamydia pneumoniae in atherosclerotic plaques of Australian patients. Pathology, 30 2: 169-172. doi:10.1080/00313029800169166


Author Paterson, David L.
Hall, Jennifer
Rasmussen, Stephanie J.
Timms, Peter
Title Failure to detect Chlamydia pneumoniae in atherosclerotic plaques of Australian patients
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 1998-05-01
Sub-type Article (original research)
DOI 10.1080/00313029800169166
Volume 30
Issue 2
Start page 169
End page 172
Total pages 4
Place of publication Abingdon, England
Publisher Informa Healthcare
Language eng
Subject 1103 Clinical Sciences
Abstract Chlamydia pneumoniae is a recently reported, but common, respiratory tract pathogen. The organism has been detected by electron microscopy, immunocytochemistry, polymerase chain reaction (PCR) and recently culture within atherosclerotic plaques, suggesting a possible association between C. pneumoniae infection and atherosclerosis. Interestingly this association has not been found by all researchers. We examined 17 carotid endarterectomy specimens, 16 carotid arteries and 16 coronary arteries from autopsy specimens. They were examined by PCR for the presence of C. pneumoniae. In none of the 49 atherosclerotic samples examined was C. pneumoniae detected. The sensitivity of our PCR assay was rigorously tested and found to detect consistently fewer than ten elementary bodies. The association between C. pneumoniae and atherosclerosis is intriguing but has not yet been demonstrated in Australian patients.
Keyword Chlamydia Pneumoniae
Atherosclerosis
Polymerase Chain Reaction
Australia
Coronary Heart-disease
Strain Twar
Serological Evidence
Enzyme-immunoassay
Artery Disease
Association
Infection
Atherectomy
Trachomatis
Antibody
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Wed, 08 Sep 2010, 03:07:28 EST