Prevalence of infection with human herpesvirus 8/Kaposi's sarcoma herpesvirus in rural South Africa

Wilkinson, D., Sheldon, J., Gilks, C.F. and Schulz, T.F. (1999) Prevalence of infection with human herpesvirus 8/Kaposi's sarcoma herpesvirus in rural South Africa. South African Medical Journal, 89 5: 554-557.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ215819_OA.pdf Full text (open access) application/pdf 2.46MB 0
Author Wilkinson, D.
Sheldon, J.
Gilks, C.F.
Schulz, T.F.
Title Prevalence of infection with human herpesvirus 8/Kaposi's sarcoma herpesvirus in rural South Africa
Journal name South African Medical Journal   Check publisher's open access policy
ISSN 0256-9574
Publication date 1999-05
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 89
Issue 5
Start page 554
End page 557
Total pages 4
Place of publication Pinelands, South Africa
Publisher Medical Association of South Africa
Language eng
Subject 1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Formatted abstract
To determine prevalence of infection with human herpesvirus 8 (HHV-8)/Kaposi's sarcoma herpesvirus (KSHV) and to gain some insight into possible transmission dynamics of this novel virus in South Africa.

Stored, anonymous serum from 50 patients with a sexually transmitted disease (STD), 50 adult medical ward patients (25 male, 25 female), and 36 paediatric ward patients in Hlabisa Hospital, KwaZulu-Natal, was screened by enzyme-linked immunosorbent assay (ELISA) for antibodies to the small capsid-related protein encoded by HHV-8/KSHV orf65. Antibodies to the latency-associated nuclear antigen (LANA) were measured by immunofluorescence, and sera that were reactive in the ELISA but negative by immunofluorescence were re-tested by Western blot against the recombinant orf65 protein to exclude nonspecific reactivity.

Overall, 47 patients tested positive (34.6%), 76 tested negative (55.9%) and 13 (9.5%) had indeterminate results. Among those with a definite result, prevalence was similar among males (47.2%) and females (52.8%) and increased in later adulthood (< 18 months 37.5%, 19-120) months 38.5%, 15-34 years 32.1%, 35-69 years 62.8%). Prevalence was highest among medical patients (58.1%); among those with an STD it was 31.1% (P = 0.01), and among children it was 22.8% (P = 0.001). When age-adjusted, prevalence among medical patients (23.7%) was similar to that among patients with an STD.

Prevalence of HHV-8/KSHV is high in this setting and transmission appears to be occurring in childhood as well as among adults. Larger population-based studies are required to detail the transmission dynamics of HHSV-8/KSHV.
Keyword Human-immunodeficiency-virus
Spindle Cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 07 Sep 2010, 13:08:28 EST