HIV-related tuberculosis in South Africa - Clinical features and outcome

Wilkinson, D. and Moore, D.A.J. (1996) HIV-related tuberculosis in South Africa - Clinical features and outcome. South African Medical Journal, 86 1: 64-67.

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Author Wilkinson, D.
Moore, D.A.J.
Title HIV-related tuberculosis in South Africa - Clinical features and outcome
Journal name South African Medical Journal   Check publisher's open access policy
ISSN 0256-9574
Publication date 1996-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 86
Issue 1
Start page 64
End page 67
Total pages 4
Place of publication Pinelands, South Africa
Publisher Medical Association of South Africa
Language eng
Subject 1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Formatted abstract
To assess the difference between human immunodeficiency virus (HIV)-infected and non-infected tuberculosis patients with regard to demographic characteristics, clinical features, case fatality rates and, particularly, compliance with therapy.

Cohort study.

Setting; Hlabisa Hospital, KwaZulu-Natal, a 450-bed hospital serving a rural district containing 180 000 people.


Two hundred and ninety-seven consecutive adult patients (> 15 years) diagnosed with tuberculosis.

Main outcome measures.
Age, sex, type of tuberculosis, case fatality rate and compliance with therapy.

A total of 107 out of 297 (36%) adults tested HIV-positive (95% confidence interval (CI) 31-42%). Prevalence of HIV infection was higher in women than men (46% v. 29%, relative risk (RR) 1.6, 95% CI 1.2-2.2). HIV-positive patients were significantly younger than HIV-negative patients (mean age 31.2 years v. 38.7 years; P < 0.001). Extrapulmonary tuberculosis (EPTB) was more common in HIV-positive patients (41% v. 11%, RR 3.7, 95% CI 2.3-5.9). The case fatality rate was higher in HIV-positive patients (13% v. 9%, RR 1.5, 95% CI 0.7-3.0). Many more HIV-positive patients failed to complete treatment (21% v. 7%, RR 3.0, 95% CI 1.5-6.0).


We found that HIV-positive patients with tuberculosis were three times more likely to fail to complete treatment than HIV-negative patients. HIV infection is clearly altering the epidemiological profile of tuberculosis in rural South Africa and poses an additional challenge to tuberculosis control programmes to maintain high case-holding rates among HIV-infected tuberculosis patients.
Keyword Developing-countries
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 07 Sep 2010, 13:07:35 EST